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Table 1 Clinical and pathological features of 14,772 TC patients

From: Novel nomogram to predict risk of bone metastasis in newly diagnosed thyroid carcinoma: a population-based study

Variables Training cohort(N = 10,340) Validation cohort(N = 4432) P value
Without BM(N = 10,268) With BM(N = 72) Without BM(N = 4384) With BM(N = 48)
Age (years) 0.757
 <50 5430 (52.9%) 10 (13.9%) 2333 (53.2%) 11 (2.3%)
 ≥ 50 4838 (47.1%) 62 (86.1%) 2051 (46.8%) 37 (97.7%)
Race 0.790
 Black 751 (7.3%) 16 (22.2%) 334 (7.6%) 7 (14.6%)
 Other a 1262 (12.3%) 7 (9.7%) 528 (12.0%) 5 (10.4%)
 White 8255 (80.4%) 49 (68.1%) 3522 (80.4%) 36 (75.0%)
Sex 0.743
 Female 7802 (76.0%) 39 (54.2%) 3348 (76.4%) 24 (50.0%)
 Male 2466 (24.0%) 33 (45.8%) 1036 (23.6%) 24 (50.0%)
Histology 0.368
 ATC 203 (2.0%) 24 (33.3%) 68 (1.6%) 11 (22.9%)
 FTC 642 (6.3%) 16 (22.2%) 272 (6.2%) 13 (27.1%)
 MTC 82 (0.8%) 2 (2.8%) 30 (0.7%) 1 (2.1%)
 PTC 9341 (91.0%) 30 (41.7%) 4014 (91.5%) 23 (47.9%)
Grade 0.092
 Grade I 8247 (80.3%) 19 (26.3%) 3525 (80.4%) 21 (43.8%)
 Grade II 1462 (14.2%) 12 (16.7%) 636 (14.5%) 5 (10.4%)
 Grade III 272 (2.6%) 10 (13.9%) 129 (2.9%) 9 (18.8%)
 Grade IV 287 (2.8%) 31 (43.1%) 94 (2.2%) 13 (27.0%)
Laterality 0.806
 Unilateral 10,201 (99.3%) 70 (97.2%) 4356 (99.4%) 48 (100.0%)
 Bilateral 67 (0.7%) 2 (2.8%) 28 (0.6%) 0 (0.0%)
T stage 0.317
 T1 5740 (55.9%) 4 (5.5%) 2460 (56.1%) 10 (20.8%)
 T2 1789 (17.4%) 8 (11.1%) 795 (18.1%) 6 (12.5%)
 T3 2165 (21.1%) 21 (29.2%) 916 (20.9%) 12 (25.0%)
 T4 574 (5.6%) 39 (54.2%) 213 (4.9%) 20 (41.7%)
N Stage 0.252
 N0 7650 (74.5%) 35 (48.6%) 3231 (73.7%) 23 (47.9%)
 N1 2618 (25.5%) 37 (51.4%) 1153 (26.3%) 25 (52.1%)
Tumor size 0.569
 <2 cm 6216 (60.5%) 8 (11.1%) 2643 (60.3%) 12 (25.0%)
 2–4 cm 1244 (12.1%) 45 (62.5%) 505 (11.5%) 28 (58.3%)
 >4 cm 2808 (27.3%) 19 (26.4%) 1236 (28.2%) 8 (16.7%)
Insurance status 0.924
 Insured 10,019 (97.6%) 71 (98.6%) 4280 (97.6%) 46 (95.8%)
 Uninsured 249 (2.4%) 1 (1.4%) 104 (2.4%) 2 (4.2%)
Marital status 0.927
 Married 6606 (64.3%) 42 (58.3%) 2821 (64.3%) 32 (66.7%)
 Unmarried 3662 (35.7%) 30 (41.7%) 1563 (35.7%) 16 (33.3%)
  1. Data notes: a Includes: American Indian, native Alaskan and Asian, Pacific Islander; PTC papillary thyroid carcinoma, FTC Follicular thyroid carcinoma, ATC Anaplastic thyroid carcinoma, MTC Medullary thyroid carcinoma
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