Table 1 Clinical and pathological features of 14,772 TC patients
Variables | Training cohort(N = 10,340) | Validation cohort(N = 4432) | P value | ||
|---|---|---|---|---|---|
Without BM(N = 10,268) | With BM(N = 72) | Without BM(N = 4384) | With BM(N = 48) | ||
Age (years) | 0.757 | ||||
<50 | 5430 (52.9%) | 10 (13.9%) | 2333 (53.2%) | 11 (2.3%) | |
≥ 50 | 4838 (47.1%) | 62 (86.1%) | 2051 (46.8%) | 37 (97.7%) | |
Race | 0.790 | ||||
Black | 751 (7.3%) | 16 (22.2%) | 334 (7.6%) | 7 (14.6%) | |
Other a | 1262 (12.3%) | 7 (9.7%) | 528 (12.0%) | 5 (10.4%) | |
White | 8255 (80.4%) | 49 (68.1%) | 3522 (80.4%) | 36 (75.0%) | |
Sex | 0.743 | ||||
Female | 7802 (76.0%) | 39 (54.2%) | 3348 (76.4%) | 24 (50.0%) | |
Male | 2466 (24.0%) | 33 (45.8%) | 1036 (23.6%) | 24 (50.0%) | |
Histology | 0.368 | ||||
ATC | 203 (2.0%) | 24 (33.3%) | 68 (1.6%) | 11 (22.9%) | |
FTC | 642 (6.3%) | 16 (22.2%) | 272 (6.2%) | 13 (27.1%) | |
MTC | 82 (0.8%) | 2 (2.8%) | 30 (0.7%) | 1 (2.1%) | |
PTC | 9341 (91.0%) | 30 (41.7%) | 4014 (91.5%) | 23 (47.9%) | |
Grade | 0.092 | ||||
Grade I | 8247 (80.3%) | 19 (26.3%) | 3525 (80.4%) | 21 (43.8%) | |
Grade II | 1462 (14.2%) | 12 (16.7%) | 636 (14.5%) | 5 (10.4%) | |
Grade III | 272 (2.6%) | 10 (13.9%) | 129 (2.9%) | 9 (18.8%) | |
Grade IV | 287 (2.8%) | 31 (43.1%) | 94 (2.2%) | 13 (27.0%) | |
Laterality | 0.806 | ||||
Unilateral | 10,201 (99.3%) | 70 (97.2%) | 4356 (99.4%) | 48 (100.0%) | |
Bilateral | 67 (0.7%) | 2 (2.8%) | 28 (0.6%) | 0 (0.0%) | |
T stage | 0.317 | ||||
T1 | 5740 (55.9%) | 4 (5.5%) | 2460 (56.1%) | 10 (20.8%) | |
T2 | 1789 (17.4%) | 8 (11.1%) | 795 (18.1%) | 6 (12.5%) | |
T3 | 2165 (21.1%) | 21 (29.2%) | 916 (20.9%) | 12 (25.0%) | |
T4 | 574 (5.6%) | 39 (54.2%) | 213 (4.9%) | 20 (41.7%) | |
N Stage | 0.252 | ||||
N0 | 7650 (74.5%) | 35 (48.6%) | 3231 (73.7%) | 23 (47.9%) | |
N1 | 2618 (25.5%) | 37 (51.4%) | 1153 (26.3%) | 25 (52.1%) | |
Tumor size | 0.569 | ||||
<2 cm | 6216 (60.5%) | 8 (11.1%) | 2643 (60.3%) | 12 (25.0%) | |
2–4 cm | 1244 (12.1%) | 45 (62.5%) | 505 (11.5%) | 28 (58.3%) | |
>4 cm | 2808 (27.3%) | 19 (26.4%) | 1236 (28.2%) | 8 (16.7%) | |
Insurance status | 0.924 | ||||
Insured | 10,019 (97.6%) | 71 (98.6%) | 4280 (97.6%) | 46 (95.8%) | |
Uninsured | 249 (2.4%) | 1 (1.4%) | 104 (2.4%) | 2 (4.2%) | |
Marital status | 0.927 | ||||
Married | 6606 (64.3%) | 42 (58.3%) | 2821 (64.3%) | 32 (66.7%) | |
Unmarried | 3662 (35.7%) | 30 (41.7%) | 1563 (35.7%) | 16 (33.3%) | |