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Table 3 Cox regression analysis of overall survival related factors in the validation cohort

From: A nuclear transport-related gene signature combined with IDH mutation and 1p/19q codeletion better predicts the prognosis of glioma patients

Variable Univariate analysis Multivariable analysis
HR (95% CI) P HR (95% CI) P
NTRS Group 3.01 (2.39-3.81) < 0.001*** 1.50 (1.14-1.98) < 0.01**
Age 1.74 (1.39-2.19) < 0.001*** / /
Gender 0.95 (0.76-1.19) 0.67 / /
Histology 1.51 (1.34-1.71) < 0.001*** 0.80 (0.69-0.93) < 0.01**
Grade 2.81 (2.38-3.30) < 0.001*** 2.75 (2.13-3.55) < 0.001***
IDH.status 0.32 (0.25-0.40) < 0.001*** 0.70 (0.53-0.92) < 0.01**
Chr.1p/19q.codeletion 0.28 (0.20-0.39) < 0.001*** 0.55 (0.37-0.82) < 0.01**
  1. NTRS (low and high); Gender (female and male); Histology (astrocytoma, oligodendroglioma, oligoastrocytoma and glioblastoma); Grade (II, III and IV); IDH status (wildtype and mutant); 1p/19q (non-codeletion and codeletion); P < 0.05 (*), P < 0.01 (**) and P < 0.001 (***) is regarded as statistically significant
  2. HR hazard ratio, CI confidence interval
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