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Table 3 Cox regression analysis of overall survival related factors in the validation cohort

From: A nuclear transport-related gene signature combined with IDH mutation and 1p/19q codeletion better predicts the prognosis of glioma patients

Variable

Univariate analysis

Multivariable analysis

HR (95% CI)

P

HR (95% CI)

P

NTRS Group

3.01 (2.39-3.81)

< 0.001***

1.50 (1.14-1.98)

< 0.01**

Age

1.74 (1.39-2.19)

< 0.001***

/

/

Gender

0.95 (0.76-1.19)

0.67

/

/

Histology

1.51 (1.34-1.71)

< 0.001***

0.80 (0.69-0.93)

< 0.01**

Grade

2.81 (2.38-3.30)

< 0.001***

2.75 (2.13-3.55)

< 0.001***

IDH.status

0.32 (0.25-0.40)

< 0.001***

0.70 (0.53-0.92)

< 0.01**

Chr.1p/19q.codeletion

0.28 (0.20-0.39)

< 0.001***

0.55 (0.37-0.82)

< 0.01**

  1. NTRS (low and high); Gender (female and male); Histology (astrocytoma, oligodendroglioma, oligoastrocytoma and glioblastoma); Grade (II, III and IV); IDH status (wildtype and mutant); 1p/19q (non-codeletion and codeletion); P < 0.05 (*), P < 0.01 (**) and P < 0.001 (***) is regarded as statistically significant
  2. HR hazard ratio, CI confidence interval
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BMC Cancer

ISSN: 1471-2407

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