Skip to main content

Table 2 Cox regression analysis of overall survival related factors in the training cohort

From: A nuclear transport-related gene signature combined with IDH mutation and 1p/19q codeletion better predicts the prognosis of glioma patients

Variable Univariate analysis Multivariable analysis
HR (95% CI) P HR (95% CI) P
NTRS Group 8.84 (6.43–12.16) < 0.001*** 2.90 (1.74–4.82) < 0.001***
Age 4.94 (3.63–6.72) < 0.001*** 2.39 (1.66–3.45) < 0.001***
Gender 0.92 (0.70–1.22) 0.58 / /
Histology 1.94 (1.66–2.25) < 0.001*** / /
Grade 4.86 (3.85–6.13) < 0.001*** 1.99 (1.51–2.62) < 0.001***
IDH.status 0.10 (0.07–0.13) < 0.001*** 0.48 (0.29–0.80) < 0.01**
Chr.1p/19q.codeletion 0.24 (0.15–0.38) < 0.001*** / /
MGMT.promoter.status 0.29 (0.22–0.39) < 0.001*** / /
Chr.7.gain&Chr.10.loss 8.75 (6.34–12.07) < 0.001*** / /
Chr.19&20 gain 3.37 (2.06–5.51) < 0.001*** 0.56 (0.34–0.93) < 0.05*
ATRX.status 0.44 (0.32–0.62) < 0.001*** / /
  1. NTRS (low and high); Gender (female and male); Histology (astrocytoma, oligodendroglioma, oligoastrocytoma and glioblastoma); Grade (II, III and IV); IDH status (wildtype and mutant); 1p/19q (non-codeletion and codeletion); MGMT promoter status (methylated and unmethylated); Chr.7.gain&Chr.10.loss (yes and no); Chr.19&20 gain (non-gain and gain); ATRX.status (wildtype and mutant)
  2. P < 0.05 (*), P < 0.01 (**) and P < 0.001 (***) is regarded as statistically significant
  3. HR hazard ratio, CI confidence interval
\