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Table 2 Cox regression analysis of overall survival related factors in the training cohort

From: A nuclear transport-related gene signature combined with IDH mutation and 1p/19q codeletion better predicts the prognosis of glioma patients

Variable

Univariate analysis

Multivariable analysis

HR (95% CI)

P

HR (95% CI)

P

NTRS Group

8.84 (6.43–12.16)

< 0.001***

2.90 (1.74–4.82)

< 0.001***

Age

4.94 (3.63–6.72)

< 0.001***

2.39 (1.66–3.45)

< 0.001***

Gender

0.92 (0.70–1.22)

0.58

/

/

Histology

1.94 (1.66–2.25)

< 0.001***

/

/

Grade

4.86 (3.85–6.13)

< 0.001***

1.99 (1.51–2.62)

< 0.001***

IDH.status

0.10 (0.07–0.13)

< 0.001***

0.48 (0.29–0.80)

< 0.01**

Chr.1p/19q.codeletion

0.24 (0.15–0.38)

< 0.001***

/

/

MGMT.promoter.status

0.29 (0.22–0.39)

< 0.001***

/

/

Chr.7.gain&Chr.10.loss

8.75 (6.34–12.07)

< 0.001***

/

/

Chr.19&20 gain

3.37 (2.06–5.51)

< 0.001***

0.56 (0.34–0.93)

< 0.05*

ATRX.status

0.44 (0.32–0.62)

< 0.001***

/

/

  1. NTRS (low and high); Gender (female and male); Histology (astrocytoma, oligodendroglioma, oligoastrocytoma and glioblastoma); Grade (II, III and IV); IDH status (wildtype and mutant); 1p/19q (non-codeletion and codeletion); MGMT promoter status (methylated and unmethylated); Chr.7.gain&Chr.10.loss (yes and no); Chr.19&20 gain (non-gain and gain); ATRX.status (wildtype and mutant)
  2. P < 0.05 (*), P < 0.01 (**) and P < 0.001 (***) is regarded as statistically significant
  3. HR hazard ratio, CI confidence interval
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BMC Cancer

ISSN: 1471-2407

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