The value of haematological parameters and serum tumour markers for predicting KRAS mutations in 784 Chinese colorectal cancer patients: a retrospective analysis

Table 4 Multivariate logistic regression analysis for the prediction of KRAS gene mutations

	Univariate P value	Multivariate P value	OR	95%CI for OR
	Univariate P value	Multivariate P value	OR	Lower	Upper
Age	0.156	0.417	1.008	0.989	1.029
CEA	0.023	0.907	1.000	0.998	1.002
CA125	0.161	0.062	0.992	0.983	0.999
CA199	0.055	0.016	1.001	1.0002	1.002
AFP	0.595	0.708	0.999	NA	1.002
SCC	0.248	0.162	0.755	0.497	1.035
NSE	0.793	0.946	1.001	0.983	1.027
CA72.4	0.922	0.042	0.992	0.983	0.999
CA15.3	0.733	0.512	0.982	0.928	1.036
FERR	0.653	0.368	1.000	0.999	1.002
CYFRA21.1	0.535	0.311	1.018	0.982	1.056
WBC	0.017	0.948	1.009	0.773	1.309
MON	0.000	0.366	0.200	0.006	6.93
MLR	0.000	0.666	0.589	0.050	6.278
Mon%	0.002	0.997	1.000	0.792	1.265
HCT	0.023	0.176	1.492	0.829	2.757
HGB	0.012	0.158	0.880	0.729	1.054
AVEMPV	0.018	0.756	0.985	0.895	1.083
MCH	0.011	0.605	1.553	0.288	8.339
MCHC	0.034	0.840	1.012	0.900	1.141
MCV	0.012	0.559	0.853	0.497	1.461
HDLC	0.031	0.116	1.746	0.872	3.521
Tumor location
Ascending colon	ref	–	–	–	–
Transverse colon	0.123	0.026	0.295	0.094	0.832
Descending colon	0.229	0.274	0.582	0.216	1.518
Sigmoid	0.001	0.006	0.363	0.173	0.744
Rectum	0.015	< 0.001	0.286	0.152	0.53

CEA Carcinoembryonic antigen, CA 125 Carbohydrate antigen 125, CA 19–9 Carbohydrate antigen 19–9, SCC Squamous cell carcinoma antigen, NSE Neuronspecific enolase, CA 724 Carbohydrate antigen 72–4, FERR Ferritin, CYFRA21-1 Human cytokeratin fragment antigen 21–1, WBC White blood cell, MON Monocyte, MLR Monocyte /Lymphocyte, HCT Hematocrit, HGB Hemoglobin, AVEMPV Mean platelet volume, MCH Mean corpuscular hemoglobin, MCHC Mean corpusular hemoglobin concerntration, MCV Mean corpuscular volume, HDLC High-density lipoprotein

ISSN: 1471-2407