|
Age > 18 years
|
Previous adverse reaction to any of the study medications
|
|
Advanced cancer
|
Australia-modified Karnofsky Performance Score < 30 at study entry
|
|
Disease-modifying therapy (surgery, chemotherapy, radiotherapy, hormone therapy, biological/targeted therapies) is unlikely to change the bowel obstruction.
|
Participated in a clinical study of a new chemical entity < 1 month before study entry
|
|
Presents with clinically confirmed bowel obstruction with vomiting that precipitates change in clinical care or a hospital admission.
|
Calculated creatinine clearance < 10 mL/minute
|
|
A partial or complete bowel obstruction for which immediate surgery is not indicated (confirmed by two consultant-level medical practitioners).
|
Clinically significant cirrhosis (documented)
|
|
Able to complete assessments and comply with the study procedures
|
Feeding or venting gastrostomy or jejunostomy
|
|
Able to give fully informed written consent
| |
|
Not currently on octreotide
| |
