Inclusion criteria | Exclusion criteria |
---|---|
Age > 18 years | Previous adverse reaction to any of the study medications |
Advanced cancer | Australia-modified Karnofsky Performance Score < 30 at study entry |
Disease-modifying therapy (surgery, chemotherapy, radiotherapy, hormone therapy, biological/targeted therapies) is unlikely to change the bowel obstruction. | Participated in a clinical study of a new chemical entity < 1 month before study entry |
Presents with clinically confirmed bowel obstruction with vomiting that precipitates change in clinical care or a hospital admission. | Calculated creatinine clearance < 10 mL/minute |
A partial or complete bowel obstruction for which immediate surgery is not indicated (confirmed by two consultant-level medical practitioners). | Clinically significant cirrhosis (documented) |
Able to complete assessments and comply with the study procedures | Feeding or venting gastrostomy or jejunostomy |
Able to give fully informed written consent | Â |
Not currently on octreotide | Â |