Age > 18 years
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Previous adverse reaction to any of the study medications
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Advanced cancer
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Australia-modified Karnofsky Performance Score < 30 at study entry
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Disease-modifying therapy (surgery, chemotherapy, radiotherapy, hormone therapy, biological/targeted therapies) is unlikely to change the bowel obstruction.
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Participated in a clinical study of a new chemical entity < 1 month before study entry
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Presents with clinically confirmed bowel obstruction with vomiting that precipitates change in clinical care or a hospital admission.
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Calculated creatinine clearance < 10 mL/minute
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A partial or complete bowel obstruction for which immediate surgery is not indicated (confirmed by two consultant-level medical practitioners).
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Clinically significant cirrhosis (documented)
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Able to complete assessments and comply with the study procedures
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Feeding or venting gastrostomy or jejunostomy
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Able to give fully informed written consent
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Not currently on octreotide
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