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Table 2 Characteristics of studies entered into the meta-analysis

From: Diagnostic value of serum HER2 levels in breast cancer: a systematic review and meta-analysis

Author Year Country No. of cases Reference method Detection method Cut-off value
Kong [17] 2006 Korea 195 IHC/FISH CLIA 15 μg/L
Olsen [22] 2007 Germany 118 IHC/FISH ELISA/ CLIA 15 ng/mL
Ludovini [23] 2008 Italy 256 IHC/FISH ELISA/ CLIA 15 ng/mL
Papadopoulou [24] 2008 Greece 56 a ELISA 1.98 ng/ml
Savino [25] 2009 Italy 85 IHC ELISA 22 ng/mL
Finn [26] 2009 579 IHC/FISH ELISA 16 ng/mL
Farzadnia [27] 2010 Iran 75 IHC ELISA 18.4 ng/ml
Lauterlein [28] 2011 Denmark 311 IHC/FISH CLIA 12.2 mg/L
Sørensen [29] 2013 Denmark 540 IHC/FISH CLIA 15 μg/L
Pedersen [30] 2013 Denmark 107 IHC/FISH CLIA 15 μg/L
Di Gioia [31] 2014 Germany 565 IHC/FISH CLIA 15 ng/mL
Di Gioia [32] 2015 Germany 241 IHC/FISH CLIA 15 ng/mL
Banys-Paluchowski [33] 2017 Germany 251 IHC/FISH ELISA 15 ng/mL
Broughton [34] 2017 Norway 149 IHC/FISH CLIA 15.2 μg/L
  1. IHC Immunohistochemistry, FISH Fluorescence in situ hybridization, CLIA Chemiluminescence immunoassay, ELISA Enzyme-linked immunosorbent assay, a only mentioned histological examination