Skip to main content

Table 2 Selected significantly enriched signaling and cell cycle pathways (KEGG and Reactome)

From: Determining the effects of trastuzumab, cetuximab and afatinib by phosphoprotein, gene expression and phenotypic analysis in gastric cancer cell lines

ID Description GeneRatio BgRatio p.adjust
MKN1 4 h Cet vs. MKN1 4 h untr
 hsa04657 IL-17 signaling pathway 6/43 79/5844 0.00121677
 hsa04668 TNF signaling pathway 6/43 102/5844 0.00259938
 hsa04010 MAPK signaling pathway 8/43 272/5844 0.01366521
 hsa04062 Chemokine signaling pathway 6/43 145/5844 0.01366521
NCI-N87 4 h Afa vs. NCI-N87 4 h untr
 hsa04668 TNF signaling pathway 11/147 102/5844 0.00964085
NCI-N87 24 h Afa vs. NCI-N87 24 h untr
 1,640,170 Cell Cycle 262/1891 462/5594 4.5934E-23
 69,278 Cell Cycle, Mitotic 221/1891 380/5594 3.1704E-21
 453,279 Mitotic G1-G1/S phases 81/1891 114/5594 8.6401E-14
 69,242 S Phase 78/1891 110/5594 2.8328E-13
 69,306 DNA Replication 68/1891 92/5594 5.238E-13
MKN1 4 h Afa vs. MKN1 4 h untr
 hsa04668 TNF signaling pathway 10/66 102/5844 2.3777E-05
 hsa04657 IL-17 signaling pathway 8/66 79/5844 0.00011952
 hsa04010 MAPK signaling pathway 11/66 272/5844 0.00427566
 hsa04064 NF-kappa B signaling pathway 5/66 82/5844 0.02329389
 hsa04621 NOD-like receptor signaling pathway 6/66 140/5844 0.0343651
 hsa04062 Chemokine signaling pathway 6/66 145/5844 0.03858289
 168,898 Toll-Like Receptors Cascades 6/60 105/5594 0.0159905
 975,155 MyD88 dependent cascade initiated on endosome 4/60 65/5594 0.04380237
 975,871 MyD88 cascade initiated on plasma membrane 4/60 65/5594 0.04380237
MKN7 4 h Afa vs. MKN7 4 h untr
 hsa04668 TNF signaling pathway 10/157 102/5844 0.02646242
 hsa04630 Jak-STAT signaling pathway 14/157 125/5844 0.00112593
MKN7 24 h Afa vs. MKN7 24 h untr
 453,279 Mitotic G1-G1/S phases 40/764 114/5594 3.6681E-06
 69,278 Cell Cycle, Mitotic 91/764 380/5594 6.4007E-06
 69,206 G1/S Transition 34/764 94/5594 7.6198E-06
 113,510 E2F mediated regulation of DNA replication 16/764 28/5594 1.4565E-05
 1,640,170 Cell Cycle 103/764 462/5594 1.4565E-05
\