Fig. 2
From: The majority of β-catenin mutations in colorectal cancer is homozygous
Differences between CTNNB1 mutations in MSI-H and MSS cancers. In MSI-H tumours CTNNB1 mutations cluster exclusively at codons 41 and 45 and mainly consist of missense mutations. In MSS cancers CTNNB1 mutations frequently cover the ß-TrcP binding site and consist of larger in frame deletions. Captation: squares white: deletion, MSI-H; squares black: deletion, MSS; circles white: missense mutation, MSI-H; circles black: missense mutation, MSS