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Fig. 1 | BMC Cancer

Fig. 1

From: The majority of β-catenin mutations in colorectal cancer is homozygous

Fig. 1

Comparison of mutated CTNNB1 allele frequencies as detected by DNA sequencing and RNA sequencing in 3 MSI-H cancers (CRC1, 9, 13). Since β-catenin is strongly expressed in cancer cells but not in contaminating lymphocytes, the level of nucleic acid contamination by lymphocytes is less for RNA than for DNA. Faint residual wild type alleles seen in CRC1 and CRC9 were considered to result from β-catenin expressing blood vessels

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