Table 3 Peak regions associated with regulated genes used for PCR validation of JMJD6 binding in ChIP assays
From: Both EZH2 and JMJD6 regulate cell cycle genes in breast cancer
Gene Symbol | Gene name | Chromosome | Chromosomal location of gene | Chromosomal location of peak | Peaks associated with /flanking genes | Distance from nearest TSS (kb) |
|---|---|---|---|---|---|---|
IGF2BP3 | Insulin Like Growth Factor 2 MRNA Binding Protein 3 | 7 | 23,349,828–23,510,086 | 23,553,064–23,553,529 | Downstream | 200 |
SIRT4 | Sirtuin 4 | 12 | 120,740,119–120,751,052 | 120,734,229–120,734,659 | Upstream | 7 |
AURKA | Aurora Kinase A | 20 | 54,944,445–54,967,393 | 54,982,773–54,983,281 | Downstream | 40 |
AURKB | Aurora Kinase B | 17 | 8,108,049–8,113,918 | 8,066,787–8,067,363 | Upstream | 40 |
ADAM17 | ADAM Metallopeptidase Domain 17 | 2 | 9,628,615–9,695,921 | 9,688,040–9,688,582 | Downstream | 60 |
RAD1 | RAD1 Checkpoint DNA Exonuclease and | 5 | 34,905,365–34,919,094 | 34,874,986–34,875,354 | Upstream | 30 |
BRIX1 | BRX1, Biogenesis Of Ribosomes | 5 | 34,915,481–34,926,101 | 34,874,986–34,875,354 | Upstream | 30 |
DNAJC21 | DnaJ Heat Shock Protein Family (Hsp40) Member C21 | 5 | 34,929,698–34,959,069 | 34,951,185–34,951,607 | Genic | – |
IDE | Insulin Degrading Enzyme | 10 | 94,211,441–94,333,852 | 94,323,996–94,324,470 | Genic | – |
PARP1 | Poly (ADP-Ribose) Polymerase 1 | 1 | 226,548,392–226,595,801 | 226,667,173–226,667,562 | Downstream | 100 |
NDRG1 | N-Myc Downstream Regulated 1 | 8 | 134,249,414–134,314,265 | 134,284,281–134,284,881 | Genic | – |
CISH | Cytokine Inducible SH2 Containing Protein | 3 | 50,643,885–50,649,262 | 50,628,326–50,628,778 | Upstream | 15 |