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Table 5 Association between clinicopathologic characteristics and HCC patient PFI through univariate and multivariate analysis with Cox regression survival model

From: Increased E2F2 predicts poor prognosis in patients with HCC based on TCGA data

Characteristics Univariate analysis Multivariate analysis
HR 95%CI P-value HR 95%CI P-value
CDK6 (high vs. low) 0.7 0.4–1.1 0.082 0.7 0.4–1.1 0.119
RB1 expression (high vs. low) 0.8 0.5–1.3 0.374 1.4 0.8–2.5 0.185
Age (>40 vs. ≤ 40) 0.7 0.4–1.3 0.268 1.0 0.5–2.1 0.959
Gender (male vs. female) 0.7 0.5–1.2 0.239 0.9 0.5–1.6 0.747
Alcohol consumption (yes vs. no) 0.9 0.5–1.6 0.804    
Histologic grade (G3–4 vs. G1–2) 1.4 1.0–1.9 0.061 1.2 0.9–1.7 0.270
M (M1 vs. M0) 4.9 0.7–36.2 0.118 0.7 0.1–6.8 0.735
N (N1 vs. N0) 3.4 0.5–24.6 0.230 0.8 0.0–89.4 0.925
T (T3–4 vs. T1–2) 1.5 1.2–2.0 0.001 0.7 0.1–5.6 0.748
Clinical stage (III-IV vs. I-II) 1.6 1.2–2.1 0.000 2.2 0.3–18.6 0.458
Postoperative ablation embolization (yes vs. no) 2.8 1.5–5.2 0.001 3.7 1.8–7.9 0.001
Radiation therapy (yes vs. no) 1.3 0.2–9.3 0.806    
Family history of cancer (yes vs. no) 1.2 0.7–2.0 0.445 1.1 0.6–1.9 0.732
Vascular invasion (yes vs. no) 1.4 0.8–2.2 0.228 1.2 0.7–2.0 0.579
E2F2 (high vs. low) 1.8 1.2–2.6 0.005 2.2 1.3–3.9 0.005
  1. PFI Progression-free interval, T = topography distribution, N = lymph node metastasis, M = distant metastasis, CI Confidence interval