Table 5 Association between clinicopathologic characteristics and HCC patient PFI through univariate and multivariate analysis with Cox regression survival model

CDK6 (high vs. low)

0.7

0.4–1.1

0.082

0.7

0.4–1.1

0.119

RB1 expression (high vs. low)

0.8

0.5–1.3

0.374

1.4

0.8–2.5

0.185

Age (>40 vs. ≤ 40)

0.7

0.4–1.3

0.268

1.0

0.5–2.1

0.959

Gender (male vs. female)

0.7

0.5–1.2

0.239

0.9

0.5–1.6

0.747

Alcohol consumption (yes vs. no)

0.9

0.5–1.6

0.804

Histologic grade (G3–4 vs. G1–2)

1.4

1.0–1.9

0.061

1.2

0.9–1.7

0.270

M (M1 vs. M0)

4.9

0.7–36.2

0.118

0.7

0.1–6.8

0.735

N (N1 vs. N0)

3.4

0.5–24.6

0.230

0.8

0.0–89.4

0.925

T (T3–4 vs. T1–2)

1.5

1.2–2.0

0.001

0.7

0.1–5.6

0.748

Clinical stage (III-IV vs. I-II)

1.6

1.2–2.1

0.000

2.2

0.3–18.6

0.458

Postoperative ablation embolization (yes vs. no)

2.8

1.5–5.2

0.001

3.7

1.8–7.9

0.001

Radiation therapy (yes vs. no)

1.3

0.2–9.3

0.806

Family history of cancer (yes vs. no)

1.2

0.7–2.0

0.445

1.1

0.6–1.9

0.732

Vascular invasion (yes vs. no)

1.4

0.8–2.2

0.228

1.2

0.7–2.0

0.579

E2F2 (high vs. low)

1.8

1.2–2.6

0.005

2.2

1.3–3.9

0.005