Outcome | RCT | NRCT | Cohort study |
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Estimate (95% CI) | Evidence quality a | Estimate (95% CI) | Evidence quality a | Estimate (95% CI) | Evidence quality a |
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Short-term outcome |
 ORR | RR 1.34 (0.91–1.98) | Moderate | RR 1.14 (0.85–1.53) | Low | RR 1.39 (0.81–2.39) | Very low |
 DCR | RR 1.11 (0.94–1.30) | Moderate | RR 1.09 (0.91–1.30) | Low | RR 1.07 (0.94–1.21) | Very low |
Survival outcome |
 OS | – | – | – | – | HR 0.68 (0.42–0.94) * | Very low |
 PFS | – | – | – | – | HR 0.71 (0.51–0.90) * | Very low |
- a The evidence quality was evaluated by GRADE. Moderate: we are moderately confident in the effect estimate (the true effect is likely to be close to the estimate of the effect, but there is a possibility that it is substantially different); Low: our confidence in the effect estimate is limited (the true effect may be substantially different from the estimate of the effect); Very low: we have very little confidence in the effect estimate (the true effect is likely to be substantially different from the estimate of effect)
- * A statistically significant difference exists (P < 0.05)