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Fig. 3 | BMC Cancer

Fig. 3

From: High proportion of anergic B cells in the bone marrow defined phenotypically by CD21(−/low)/CD38- expression predicts poor survival in diffuse large B cell lymphoma

Fig. 3

High proportion of Anergic B cells in the BM is significantly associated with negative survival outcome at 5 years independent of BM involvement. Proportions of anergic B cells in the BM of DLBCL patients at diagnosis were quantified using multicolor flow cytometry. Survival outcome at 5-years (yes/no) data was available on N = 24 BM samples but presence of clonal cells was detected in N = 9 of BM cases which were excluded in this analysis. The presence of these cells was determined and recorded previously as cells having an abnormal kappa: lambda light chain ratio with normal expression defined as 3:2 on flow cytometry. Comparison was made using exact non-parametric Mann-Whitney U test. For this analysis, p < .05 was taken to be significant. Graph represents mean ± SD

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