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Fig. 3 | BMC Cancer

Fig. 3

From: Cell type-specific genotoxicity in estrogen-exposed ovarian and fallopian epithelium

Fig. 3

DSB recruitment of HR proteins upon estrogen induction. a-b, IF staining (a) and quantification (b) for phosphor-BRCA1 in cryosectioned ovarian cancer at indicated stages. p values were calculated between two indicated groups by unpaired t-test. p values: unpaired t-test. c-e, Representative images and quantifications for phosphorylated RPA (pSerine 33, c), BRCA1 (pSerine 1524, d) and RAD51 (e) upon estrogen treatment. Similar to 53BP1 foci formation, levels of these protein at DSBs were elevated upon estrogen treatment

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