Table 4 Correlation between cfDNA and clinical tumor burden
Tumor burden | cfDNA concentration (ng/ml) | cfDNA content (ng) | Mutational frequency (%) | |||
|---|---|---|---|---|---|---|
P value | Pearson r(95%CI) | P value | Pearson r(95%CI) | P value | Pearson r(95%CI) | |
CEA (ng/ml) | < 0.0001 | 0.81 (0.74–0.87) | < 0.0001 | 0.84 (0.78–0.89) | < 0.0001 | 0.56 (0.35–0.72) |
CA199 (U/ml) | < 0.0001 | 0.66 (0.54–0.75) | < 0.0001 | 0.63 (0.50–0.73) | < 0.0001 | 0.66 (0.48–0.79) |
CA125 (U/ml) | < 0.0001 | 0.59 (0.44–0.71) | < 0.0001 | 0.65 (0.51–0.75) | 0.0036 | 0.42 (0.15–0.63) |
NSE (ng/ml) | < 0.0001 | 0.65 (0.49–0.77) | < 0.0001 | 0.67 (0.51–0.78) | 0.0022 | 0.50 (0.20–0.71) |
LDH (U/L) | < 0.0001 | 0.84 (0.78–0.89) | < 0.0001 | 0.86 (0.80–0.90) | < 0.0001 | 0.61 (0.39–0.76) |
Sum of diameter (mm) | < 0.0001 | 0.80 (0.72–0.85) | < 0.0001 | 0.76 (0.68–0.83) | < 0.0001 | 0.64 (0.46–0.77) |