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Table 3 Published studies on DTC status in the bone marrow for peri-ampullary adenocarcinomas, grouped by detection method

From: Cytokeratin-positive cells in the bone marrow from patients with pancreatic, periampullary malignancy and benign pancreatic disease show no prognostic information

Authors Method/ Markers Detection limit DTC def. Pat. number Loc. / Adv. TC-rate false-pos. Rate Prog. Comments
Immunocytochemistry
 Effenberger 2012 [13] CK A45-B/B3 ≥1 / 2 × 106 MNC TC n = 175 n = 71 / n = 104 13.7% (24/175) Pos. 29 pat. Resected despite advanced cancer stage
 Rehders 2012 [25] CK A45-B/B3 ≥1 / 1 × 106 MNC TC n = 49 n = 49 /- 27% (12/49) Neg. No details on survival analysis disclosed
 Roder 1999 [17] CK 2; KL1; A45-B7B3 ≥1 / 5 × 105 MNC TC n = 48 n = 8 / n = 40 52.1% (25/48) Pos. Association with OS for resected patients
 van Heek 2001 [16] CK (8, 18) ≥1 / 1 × 107 MNC TC n = 35 n = 14 / n = 13 34.2% (12/35) 50%(2/4) Pos. 2/4 benign pat. False positive
 Vogel 1999 [14] panCK, mucin, CEA, Ca-19–9 ≥1 / 1.25 × 106 TC n = 80 n = 11 / n = 60 38%(27/71) 6.6%(3/45) Pos.  
 Thorban 1996 [15] CK A45-B/B3 ≥1 / 5 × 105 MNC TC n = 42 n = 24 / n = 18 57.1% (24/42) Pos. Association with metastatic and local relapse
 Z’Graggen 2001 [26] CK AE3/AE1 ≥1 / 5 × 106 MNC TC n = 54 n = 3 / n = 51 24% (13/54) 4.1%(1/24) Neg.  
Nucleotide based detection
 Hoffmann 2007 [24] rt-PCR / CK-19   n = 37 n = 7 / n = 30 67%(25/37) Neg.  
 Soeth 2005 [23] rt-PCR / CK-20   n = 117 n = 172 33.3%(45/135) 11% Neg. Survival data only for blood/BM combined. False positive rate 11%
  1. Prog Prognostic impact of DTC-status on survival Loc Localised cancers; Adv Advanced cancers; MNC Mononuclear cells
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