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Table 2 Overall survival according to ICC-positive cell type status in bone marrow

From: Cytokeratin-positive cells in the bone marrow from patients with pancreatic, periampullary malignancy and benign pancreatic disease show no prognostic information

ICC-type

Level

N

Incidentcases

Person months

HR(95%CI)

p-value

Mean OS(95%CI)

Overall survival, resected cancers

TC

Positive

6

5

217.5

1.1 (0.4–2.3)

0.865

36.2 (11.3–61.2)

Negative

162

133

5293.6

  

37.1 (31.6–42.6)

UIC

Positive

10

7

488.1

0.6 (0.3–1.3)

0.197

52.5 (27.2–77.7)

Negative

164

136

5144.0

  

35. 6 (30.2–40.9)

HC

Positive

16

14

431.6

1.3 (0.7–2.2)

0.386

29.6 (14.3–44.8)

Negative

153

125

5006.5

  

37.3 (31.6–43.1)

QHC

Positive

12

10

419.0

0.9 (.5–1.8)

0.795

37.1 (18.1–56.0)

Negative

123

102

3817.1

  

35.5 (29.2–41.8)

Overall survival, advanced cancers

TC

Positive

2

2

7.9

3.4 (0.7–15.4)

0.114

3.9 (0.8–7.1)s

Negative

29

29

298.8

  

10.3 (7.4–13.2)

UIC

Positive

0

0

 

 

Negative

31

31

306.6

  

9.9 (7.1–12.7)

HC

Positive

2

2

14.3

1.6 (0.4–7.2)

0.522

7.2 (4.0–10.3)

Negative

28

28

266.6

  

9.5 (6.5–12.5)

QHC

Positive

3

3

16.6

2.1 (0.6–7.2)

0.262

5.5 (1.9–9.2)

Negative

25

25

248.5

  

9.9 (6.5–13.4)

Overall survival, benign disease

TC

Positive

4

2

256.1

4.0 (0.7–22.6)

0.114

65.3 (53.0–77.6)

Negative

25

7

1929.4

  

92.2 (82.7–101.7)

UIC

Positive

2

2

143.0

5.7 (1.1–25.5)

0.039

71.5 (52.9–90.1)

Negative

28

7

1796.9

  

92.6 (83.2–101.9)

HC

Positive

3

2

202.3

4.7 (0.9–25.7)

0.075

69.4 (43.1–95.7)

Negative

26

6

1867.3

  

93.7 (84.3–103.2)

QHC

Positive

3

2

202.3

3.9 (0.7–21.6)

0.114

5.5 (1.9–9.2)

Negative

22

5

1639.1

  

9.9 (6.5–13.4)

Disease free survival, resected cancers

TC

Positive

6

6

112.4

1.3 (0.6–3.0)

0.525

18.7 (4.5–33.0)

Negative

162

126

4022.2

  

32.2 (25.9–38.5)

UIC

Positive

10

5

441.8

0.4 (0.2–1.0)

0.040

62.1 (37.1–87.1)

Negative

164

132

3785.8

  

29.4 (23.5–35.4)

HC

Positive

16

16

299.4

1.4 (0.8–2.5)

0.277

22.6 (5.7–39.5)

Negative

153

120

3774.0

  

31.9 (25.5–38.3)

QHC

Positive

12

10

340.7

1.0 (0.5–1.9)

0.973

30.1 (10. 1–50.8)

Negative

123

96

2825.6

  

30.8 (23.7–37.8)

  1. Detailed survival analysis for patients with (pos.) or without (neg.) ICC-positive cells in the bone marrow in the indicated morphological cell categories. HR and p-values were computed by Cox-regression analysis. The number of patients analysed may differ from group size for cases with inconclusive ICC-results