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Table 4 Uni- and multivariate analyses of factors associated with 3-year overall survival (OS) and recurrence-free survival (RFS) rates in gMANEC patients

From: Effect of sarcopenia on short- and long-term outcomes in patients with gastric neuroendocrine neoplasms after radical gastrectomy: results from a large, two-institution series

Variable

Univariate analysis

Multivariate analysis

Univariate analysis

Multivariate analysis

3-year OS

3-year OS

3-year RFS

3-year RFS

HR (95% CI)

P

HR (95% CI)

P

HR (95% CI)

P

HR (95% CI)

P

Gender

 Male

1

   

1

   

 Female

0.788 (0.341–1.823)

0.578

  

1.020 (0.431–2.412)

0.964

  

Age (years)

 < 65

1

   

1

   

 ≥ 65

1.234 (0.616–2.472)

0.554

  

0.929 (0.431–2.002)

0.851

  

BMI(kg/m2)

 < 25

1

   

1

   

 ≥ 25

0.856 (0.300–2.442)

0.772

  

0.809 (0.243–2.687)

0.729

  

ASA

 1

1

 

1

 

1

 

1

 

 2

2.261 (1.038–4.929)

0.04

1.548 (0.701–3.422)

0.280

2.573 (1.141–5.801)

0.041

2.089 (0.917–4.758)

0.080

 3

3.732 (1.371–10.156)

0.01

1.898 (0.628–5.730)

0.256

1.563 (0.429–5.695)

0.499

0.744 (0.197–2.813)

0.663

Comorbidity

 No

1

   

1

   

 Yes

0.846 (0.401–1.789)

0.662

  

0.528 (0.245–1.139)

0.104

  

Tumor (mm)

 < 50

1

   

1

   

 ≥ 50

1.528 (0.754–3.098)

0.239

  

1.264 (0.591–2.701)

0.546

  

Tumor location

 Upper

1

   

1

   

 Middle

0.573 (0.188–1.741)

0.326

  

0.802 (0.255–2.521)

0.706

  

 Lower

0.852 (0.369–1.970)

0.708

  

1.100 (0.456–2.656)

0.832

  

 Mix

1.625 (0.583–4.531)

0.353

  

1.140 (0.317–4.094)

0.841

  

 T stage

        

 T1 + T2

1

 

1

 

1

   

 T3 + T4

2.197 (1.082–4.464)

0.029

2.145 (0.985–4.668)

0.055

1.753 (0.818–3.756)

0.149

  

 N stage

        

 N0

1

 

1

 

1

 

1

 

 N1

4.586 (1.756–11.979)

0.002

3.134 (1.148–8.551)

0.026

4.558 (1.568–13.249)

0.005

3.956 (1.313–11.917)

0.015

Surgical method

 Open

1

   

1

   

 Laparoscopic

0.698 (0.330–1.474)

0.346

  

0.778 (0.340–1.779)

0.552

  

Gastrectomy extent

 Total

1

   

1

   

 Distal

0.691 (0.310–1.540)

0.366

  

1.201 (0.539–2.673)

0.654

  

 Proximal

0 (0)

0.982

  

0(0)

0.984

  

Ki-67 positive index (%)

 < 60

1

 

1

 

1

 

1

 

 ≥ 60

4.874 (1.872–12.689)

0.001

3.710(1.372–10.033)

0.010

11.553(2.729–48.913)

0.001

8.210(1.912–35.256)

0.005

Complication

 No

1

   

1

   

 Yes

1.645 (0.820–3.298)

0.161

  

1.200 (0.525–2.742)

0.666

  

Adjuvant chemotherapy

 No

1

   

1

   

 Yes

1.428 (0.697–2.925)

0.33

  

1.248 (0.579–2.691)

0.572

  

Martin et al. [27]

 High

1

   

1

   

 Low

1.667 (0.789–3.523)

0.181

  

1.868 (0.817–4.272)

0.138

  

 SMI

        

 High

1

 

1

 

1

 

1

 

 Low

2.639 (1.270–5.483)

0.009

2.735 (1.246–6.001)

0.012

2.356 (1.077–5.153)

0.032

2.825 (1.250–6.386)

0.013

  1. gMANEC gastric mixed adenoneuroendocrine carcinoma, HR Hazard ratio, CI Confidence interval, BMI Body mass index, ASA American Society of Anesthesiologists, SMI Skeletal muscle index