|
Variable
|
Univariate analysis
|
Multivariate analysis
|
Univariate analysis
|
Multivariate analysis
|
|---|
|
3-year OS
|
3-year OS
|
3-year RFS
|
3-year RFS
|
|---|
|
HR (95% CI)
|
P
|
HR (95% CI)
|
P
|
HR (95% CI)
|
P
|
HR (95% CI)
|
P
|
|---|
|
Gender
|
|
Male
|
1
| | | |
1
| | | |
|
Female
|
0.788 (0.341–1.823)
|
0.578
| | |
1.020 (0.431–2.412)
|
0.964
| | |
|
Age (years)
|
|
< 65
|
1
| | | |
1
| | | |
|
≥ 65
|
1.234 (0.616–2.472)
|
0.554
| | |
0.929 (0.431–2.002)
|
0.851
| | |
|
BMI(kg/m2)
|
|
< 25
|
1
| | | |
1
| | | |
|
≥ 25
|
0.856 (0.300–2.442)
|
0.772
| | |
0.809 (0.243–2.687)
|
0.729
| | |
|
ASA
|
|
1
|
1
| |
1
| |
1
| |
1
| |
|
2
|
2.261 (1.038–4.929)
|
0.04
|
1.548 (0.701–3.422)
|
0.280
|
2.573 (1.141–5.801)
|
0.041
|
2.089 (0.917–4.758)
|
0.080
|
|
3
|
3.732 (1.371–10.156)
|
0.01
|
1.898 (0.628–5.730)
|
0.256
|
1.563 (0.429–5.695)
|
0.499
|
0.744 (0.197–2.813)
|
0.663
|
|
Comorbidity
|
|
No
|
1
| | | |
1
| | | |
|
Yes
|
0.846 (0.401–1.789)
|
0.662
| | |
0.528 (0.245–1.139)
|
0.104
| | |
|
Tumor (mm)
|
|
< 50
|
1
| | | |
1
| | | |
|
≥ 50
|
1.528 (0.754–3.098)
|
0.239
| | |
1.264 (0.591–2.701)
|
0.546
| | |
|
Tumor location
|
|
Upper
|
1
| | | |
1
| | | |
|
Middle
|
0.573 (0.188–1.741)
|
0.326
| | |
0.802 (0.255–2.521)
|
0.706
| | |
|
Lower
|
0.852 (0.369–1.970)
|
0.708
| | |
1.100 (0.456–2.656)
|
0.832
| | |
|
Mix
|
1.625 (0.583–4.531)
|
0.353
| | |
1.140 (0.317–4.094)
|
0.841
| | |
|
T stage
| | | | | | | | |
|
T1 + T2
|
1
| |
1
| |
1
| | | |
|
T3 + T4
|
2.197 (1.082–4.464)
|
0.029
|
2.145 (0.985–4.668)
|
0.055
|
1.753 (0.818–3.756)
|
0.149
| | |
|
N stage
| | | | | | | | |
|
N0
|
1
| |
1
| |
1
| |
1
| |
|
N1
|
4.586 (1.756–11.979)
|
0.002
|
3.134 (1.148–8.551)
|
0.026
|
4.558 (1.568–13.249)
|
0.005
|
3.956 (1.313–11.917)
|
0.015
|
|
Surgical method
|
|
Open
|
1
| | | |
1
| | | |
|
Laparoscopic
|
0.698 (0.330–1.474)
|
0.346
| | |
0.778 (0.340–1.779)
|
0.552
| | |
|
Gastrectomy extent
|
|
Total
|
1
| | | |
1
| | | |
|
Distal
|
0.691 (0.310–1.540)
|
0.366
| | |
1.201 (0.539–2.673)
|
0.654
| | |
|
Proximal
|
0 (0)
|
0.982
| | |
0(0)
|
0.984
| | |
|
Ki-67 positive index (%)
|
|
< 60
|
1
| |
1
| |
1
| |
1
| |
|
≥ 60
|
4.874 (1.872–12.689)
|
0.001
|
3.710(1.372–10.033)
|
0.010
|
11.553(2.729–48.913)
|
0.001
|
8.210(1.912–35.256)
|
0.005
|
|
Complication
|
|
No
|
1
| | | |
1
| | | |
|
Yes
|
1.645 (0.820–3.298)
|
0.161
| | |
1.200 (0.525–2.742)
|
0.666
| | |
|
Adjuvant chemotherapy
|
|
No
|
1
| | | |
1
| | | |
|
Yes
|
1.428 (0.697–2.925)
|
0.33
| | |
1.248 (0.579–2.691)
|
0.572
| | |
|
Martin et al. [27]
|
|
High
|
1
| | | |
1
| | | |
|
Low
|
1.667 (0.789–3.523)
|
0.181
| | |
1.868 (0.817–4.272)
|
0.138
| | |
|
SMI
| | | | | | | | |
|
High
|
1
| |
1
| |
1
| |
1
| |
|
Low
|
2.639 (1.270–5.483)
|
0.009
|
2.735 (1.246–6.001)
|
0.012
|
2.356 (1.077–5.153)
|
0.032
|
2.825 (1.250–6.386)
|
0.013
|
- gMANEC gastric mixed adenoneuroendocrine carcinoma, HR Hazard ratio, CI Confidence interval, BMI Body mass index, ASA American Society of Anesthesiologists, SMI Skeletal muscle index
