Table 3 Uni- and multivariate analyses of factors associated with 3-year overall survival (OS) and recurrence-free survival (RFS) rates in g-NENs patients

 Male

1

1

 Female

0.650 (0.338–1.248)

0.195

0.813 (0.419–1.580)

0.542

 < 65

1

1

 ≥ 65

1.112 (0.669–1.847)

0.683

0.851 (0.488–1.483)

0.569

 < 25

1

1

 ≥ 25

0.694 (0.330–1.460)

0.336

0.709 (0.320–1.570)

0.396

 1

1

1

1

1

 2

1.934 (1.118–3.347)

0.018

1.869 (1.069–3.269)

2.118 (1.196–3.749)

0.010

2.191 (1.223–3.924)

 3

2.54 (1.172–5.504)

0.018

2.029 (0.917–4.486)

1.294 (0.487–3.437)

0.605

0.875 (0.324–2.361)

 No

1

1

 Yes

1.346 (0.751–2.411)

0.318

0.993 (0.552–1.785)

0.981

 < 50

1

1

 ≥ 50

1.596 (0.957–2.659)

0.073

1.449 (0.841–2.496)

0.181

 Upper

1

1

 Middle

0.664 (0.314–1.403)

0.283

0.778 (0.349–1.734)

0.540

 Lower

0.917 (0.484–1.735)

0.789

1.104 (0.571–2.135)

0.769

 Mix

1.253 (0.593–2.649)

0.555

1.147 (0.494–2.664)

0.749

 T1 + T2

1

1

1

 T3 + T4

1.748 (1.054–2.898)

0.031

1.445 (0.843–2.476)

1.568 (0.914–2.691)

0.103

 N0

1

1

1

1

 N1

5.032 (2.385–10.616)

<.001

3.554 (1.624–7.778)

5.882 (2.507–13.804)

<.001

4.710 (1.966–11.283)

 Open

1

1

 Laparoscopic

0.797 (0.472–1.344)

0.395

0.875 (0.496–1.546)

0.647

 Total

1

1

 Distal

0.74 (0.400–1.368)

0.337

1.080 (0.584–1.994)

0.807

 Proximal

0.418 (0.058–3.029)

0.388

0.528 (0.072–3.850)

0.529

 NET

1

1

 NEC

2.352 (0.712–7.773)

0.161

1.521 (0.524–4.414)

0.441

 MANEC

1.839 (0.563–6.008)

0.313

1.172 (0.410–3.350)

0.767

 < 60

1

1

1

1

 ≥ 60

4.753 (2.469–9.152)

<.001

3.492 (1.772–6.879)

5.978 (2.810–12.718)

<.001

4.304 (1.981–9.350)

 No

1

1

 Yes

1.645 (0.994–2.723)

0.053

1.245 (0.699–2.220)

0.457

 No

1

1

 Yes

1.409 (0.843–2.355)

0.191

1.559 (0.894–2.719)

0.117

 High

1

1

 Low

1.181 (0.709–1.968)

0.523

1.377 (0.790–2.400)

0.260

 SMI

 High

1

1

1

1

 Low

2.061 (1.243–3.420)

0.005

2.098 (1.239–3.553)

1.758 (1.025–3.018)

0.041

1.780 (1.029–3.076)