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Table 2 Pre-existing comorbidities in non-transplant and transplant patients with NDMM stratified by age

From: Frontline treatment patterns and attrition rates by subsequent lines of therapy in patients with newly diagnosed multiple myeloma

  Overall < 65 years 65–74 years 75–84 years 85+ years
Non-transplant (N = 22,062) Transplant (N = 2763) Non-transplant (n = 5197) Transplant (n = 1378) Non-transplant (n = 7741) Transplant (n = 1298) Non-transplant (n = 7536) Transplant (n = 87) Non-transplant (n = 1588) Transplant (n = 0)
Charlson Comorbidity Index during 180 days prior to index MM diagnosis
 Mean (SD) 1.5 (1.8) 1.2 (1.5) 0.9 (1.6) 0.7 (1.3) 1.5 (1.8) 1.6 (1.6) 1.6 (1.8) 1.5 (1.3) 2.1 (1.9)
 Median (Q1–Q3) 1.0 (0–2.0) 1.0 (0–2.0) 0 (0–1.0) 0 (0–1.0) 1.0 (0–2.0) 2.0 (0–2.0) 1.0 (0–2.0) 2.0 (0–2.0) 2.0 (0–3.0)
 Min, max 0, 13 0, 11 0, 13 0, 9 0, 12 0, 11 0, 12 0, 5 0, 10
Comorbidities during 180 days prior to index MM diagnosis, n (%)
 Any comorbidity below 14,539 (65.9) 1638 (59.3) 2556 (49.2) 746 (54.1) 5186 (67.0) 826 (63.6) 5476 (72.7) 66 (75.9) 1321 (83.2)
 Cardiac arrhythmia 4327 (19.6) 294 (10.6) 529 (10.2) 139 (10.1) 1396 (18.0) 143 (11.0) 1854 (24.6) 12 (13.8) 548 (34.5)
 Congestive heart failure 2984 (13.5) 117 (4.2) 493 (9.5) NR 956 (12.3) 59 (4.5) 1179 (15.6) NR 356 (22.4)
 Hypertension, complicated 3718 (16.9) 260 (9.4) 603 (11.6) NR 1274 (16.5) 143 (11.0) 1435 (19.0) NR 406 (25.6)
 Hypertension, simple 11,698 (53.0) 1316 (47.6) 1871 (36.0) 569 (41.3) 4215 (54.5) 692 (53.3) 4490 (59.6) 55 (63.2) 1122 (70.7)
 Hepatic disease 972 (4.4) 151 (5.5) 269 (5.2) NR 392 (5.1) 71 (5.5) 241 (3.2) NR 70 (4.4)
 Pulmonary circulation disorders 1027 (4.7) 56 (2.0) 172 (3.3) NR 357 (4.6) 23 (1.8) 388 (5.1) NR 110 (6.9)
 Renal impairment 5317 (24.1) 471 (17.0) 932 (17.9) 230 (16.7) 1829 (23.6) 222 (17.1) 2028 (26.9) 19 (21.8) 528 (33.2)
 Valvular disease 2258 (10.2) 158 (5.7) 282 (5.4) NR 744 (9.6) 90 (6.9) 966 (12.8) NR 266 (16.8)
  1. MM Multiple myeloma, NDMM Newly diagnosed multiple myeloma, NR Not reported, Q Quartile, SD Standard deviation
  2. Values of 1–10 have not been reported in any cell in this table to conform to the Centers for Medicare and Medicaid Services cell size suppression policy; Similarly, values have not been reported for categorical variables and by subgroup to avoid making it possible to calculate the values of the NR cells
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