Ā | Total | Limb Salvage (nĀ =ā1316) | Amputation (nĀ =ā409) | ||||||
---|---|---|---|---|---|---|---|---|---|
HR | P | 95% CI | HR | P | 95% CI | HR | P | 95% CI | |
Surgery Type | Ā | Ā | Ā | 0.71 | 0.000 | 0.59ā0.85 | 1.42 | 0.001 | 1.13ā1.63 |
Age; median (IQR) | 1.02 | 0.000 | 1.01ā1.02 | 1.02 | 0.000 | 1.01ā1.02 | 1.01 | 0.001 | 1.01ā1.02 |
ā<ā20 | Reference | Ā | Ā | Ā | Ā | Ā | Ā | Ā | Ā |
ā20ā39 | 1.15 | 0.195 | 0.93ā1.42 | 1.11 | 0.413 | 0.86ā1.44 | 1.12 | 0.549 | 0.77ā1.64 |
ā40ā59 | 1.29 | 0.056 | 0.99ā1.67 | 1.33 | 0.076 | 0.97ā1.82 | 1.20 | 0.446 | 0.75ā1.94 |
ā60+ | 2.33 | 0.000 | 1.72ā3.16 | 2.57 | 0.000 | 1.74ā3.8 | 1.94 | 0.010 | 1.17ā3.21 |
Sex | |||||||||
āMale | Ā | Ā | Ā | Ā | Ā | Ā | Ā | Ā | Ā |
āFemale | 0.87 | 0.111 | 0.73ā1.03 | 0.79 | 0.030 | 0.64ā0.98 | 1.10 | 0.530 | 0.82ā1.49 |
Race | |||||||||
āWhite | Reference | Ā | Ā | Ā | Ā | Ā | Ā | Ā | Ā |
āBlack | 0.98 | 0.834 | 0.78ā1.22 | 0.82 | 0.172 | 0.61ā1.09 | 1.29 | 0.160 | 0.9ā1.85 |
āAsian/Pacific Islander | 1.01 | 0.974 | 0.66ā1.53 | 1.14 | 0.619 | 0.69ā1.88 | 0.75 | 0.465 | 0.35ā1.61 |
āOther/Unknown | 1.36 | 0.107 | 0.94ā1.99 | 1.27 | 0.321 | 0.8ā2.01 | 1.63 | 0.139 | 0.85ā3.1 |
Insurance Status | |||||||||
āUninsured | 0.87 | 0.452 | 0.59ā1.26 | 0.87 | 0.556 | 0.55ā1.39 | 0.94 | 0.837 | 0.5ā1.75 |
āInsured | Reference | Ā | Ā | Ā | Ā | Ā | Ā | Ā | Ā |
āMedicaid | 0.69 | 0.001 | 0.55ā0.85 | 0.61 | 0.000 | 0.47ā0.8 | 0.85 | 0.38 | 0.59ā1.22 |
āMedicare | 1.53 | 0.006 | 1.13ā2.07 | 1.17 | 0.461 | 0.77ā1.77 | 2.29 | 0.001 | 1.44ā3.65 |
Zipcode Income | |||||||||
ā<ā$38,000 | Reference | Ā | Ā | Ā | Ā | Ā | Ā | Ā | Ā |
ā$38,000ā$47,999 | 0.81 | 0.099 | 0.64ā1.04 | 0.65 | 0.007 | 0.48ā0.89 | 1.17 | 0.450 | 0.78ā1.76 |
ā$48,000ā$62,999 | 0.77 | 0.032 | 0.6ā0.98 | 0.87 | 0.342 | 0.65ā1.16 | 0.62 | 0.033 | 0.4ā0.96 |
ā$63,000+ | 0.92 | 0.468 | 0.72ā1.16 | 1.01 | 0.950 | 0.76ā1.34 | 0.77 | 0.250 | 0.49ā1.2 |
Zipcode Education | |||||||||
ā21% or more | Reference | Ā | Ā | Ā | Ā | Ā | Ā | Ā | Ā |
ā13ā20.9% | 0.96 | 0.713 | 0.75ā1.22 | 0.91 | 0.551 | 0.68ā1.23 | 1.06 | 0.769 | 0.71ā1.6 |
ā7ā12.9% | 0.90 | 0.356 | 0.71ā1.13 | 0.94 | 0.678 | 0.71ā1.25 | 0.84 | 0.424 | 0.56ā1.28 |
ā<ā7% | 0.98 | 0.851 | 0.76ā1.25 | 1.11 | 0.484 | 0.82ā1.5 | 0.73 | 0.176 | 0.46ā1.15 |
Urban | |||||||||
āMetro | 0.49 | 0.016 | 0.28ā0.87 | 0.48 | 0.108 | 0.2ā1.17 | 0.60 | 0.187 | 0.28ā1.28 |
āUrban | 0.52 | 0.035 | 0.29ā0.96 | 0.55 | 0.196 | 0.22ā1.37 | 0.57 | 0.193 | 0.25ā1.32 |
āRural | Reference | Ā | Ā | Ā | Ā | Ā | Ā | Ā | Ā |
Distance from Hospital (Miles); mean (95% CI) | 1.00 | 0.547 | 1ā1 | 1.00 | 0.536 | 1ā1 | 1.00 | 0.982 | 1ā1 |
Year of Diagnosis | 1.00 | 0.771 | 0.98ā1.03 | 0.99 | 0.585 | 0.96ā1.03 | 1.04 | 0.083 | 0.99ā1.1 |
ā<ā2006 | Reference | Ā | Ā | Ā | Ā | Ā | Ā | Ā | Ā |
ā2006ā2010 | 1.06 | 0.614 | 0.84ā1.33 | 1.01 | 0.935 | 0.77ā1.34 | 1.18 | 0.414 | 0.79ā1.77 |
ā2011ā2015 | 1.01 | 0.949 | 0.78ā1.3 | 0.91 | 0.529 | 0.67ā1.23 | 1.40 | 0.138 | 0.9ā2.18 |
Location | |||||||||
āLower Limb | Reference | Ā | Ā | Ā | Ā | Ā | Ā | Ā | Ā |
āUpper Limb | 1.52 | 0.000 | 1.23ā1.89 | 1.38 | 0.013 | 1.07ā1.78 | 2.24 | 0.000 | 1.51ā3.33 |
Long vs Short Bone | |||||||||
āShort Bone | Reference | Ā | Ā | Ā | Ā | Ā | Ā | Ā | Ā |
āLong Bone | 3.89 | 0.000 | 2.44ā6.19 | 2.25 | 0.007 | 1.24ā4.06 | 6.68 | 0.000 | 3.2ā13.95 |
AJCC Clinical Stage | |||||||||
āStage 1A or 1B | Ā | Ā | Ā | Ā | Ā | Ā | Ā | Ā | Ā |
āStage 2A or 2B | Reference | Ā | Ā | Ā | Ā | Ā | Ā | Ā | Ā |
āStage 3 | 1.34 | 0.195 | 0.86ā2.07 | 1.70 | 0.045 | 1.01ā2.87 | 0.79 | 0.573 | 0.35ā1.79 |
āStage 4A or 4B | 2.82 | 0.000 | 2.33ā3.4 | 2.88 | 0.000 | 2.28ā3.64 | 2.73 | 0.000 | 1.96ā3.78 |
Osteosarcoma Type | |||||||||
āOsteosarcoma NOS | Ā | Ā | Ā | Ā | Ā | Ā | Ā | Ā | Ā |
āChondroblastic | 0.90 | 0.324 | 0.74ā1.11 | 1.07 | 0.573 | 0.84ā1.37 | 0.65 | 0.023 | 0.45ā0.94 |
āFibroblastic | 0.63 | 0.067 | 0.39ā1.03 | 0.46 | 0.024 | 0.24ā0.9 | 1.15 | 0.708 | 0.56ā2.34 |
āTelangiectatic | 0.95 | 0.775 | 0.65ā1.38 | 0.96 | 0.870 | 0.61ā1.51 | 0.99 | 0.974 | 0.48ā2.03 |
āCentral | 0.71 | 0.288 | 0.38ā1.34 | 0.76 | 0.461 | 0.37ā1.56 | 0.79 | 0.740 | 0.19ā3.2 |
āSurface/Juxtacortical | Ā | Ā | Ā | Ā | Ā | Ā | Ā | Ā | Ā |
Tumor Size (cm); mean (95% CI) | 1.01 | 0.002 | 1ā1.01 | 1.00 | 0.174 | 1ā1.01 | 1.02 | 0.000 | 1.01ā1.03 |
ā<ā8ācm | Reference | Ā | Ā | Ā | Ā | Ā | Ā | Ā | Ā |
ā>ā8ācm | 1.68 | 0.000 | 1.38ā2.04 | 1.44 | 0.002 | 1.15ā1.81 | 2.27 | 0.000 | 1.53ā3.39 |
Presence of Metastases at Dx | |||||||||
āNo metastases | Reference | Ā | Ā | Ā | Ā | Ā | Ā | Ā | Ā |
āmetastases | 2.93 | 0.000 | 2.44ā3.53 | 3.00 | 0.000 | 2.39ā3.76 | 2.79 | 0.000 | 2.02ā3.86 |
Comorbidities at Dx | |||||||||
āNo comorbidities | Reference | Ā | Ā | Ā | Ā | Ā | Ā | Ā | Ā |
ā1 or more | 1.02 | 0.916 | 0.77ā1.34 | 0.86 | 0.429 | 0.6ā1.24 | 1.30 | 0.247 | 0.83ā2.01 |
Received Adjuvant Chemotherapy | Ā | Ā | Ā | Ā | Ā | Ā | Ā | Ā | Ā |
āNo | Reference | Ā | Ā | Ā | Ā | Ā | Ā | Ā | Ā |
āYes | 0.58 | 0.001 | 0.42ā0.79 | 0.80 | 0.326 | 0.51ā1.25 | 0.38 | 0.000 | 0.24ā0.59 |
Surgical Margins | |||||||||
āClear | Reference | Ā | Ā | Ā | Ā | Ā | Ā | Ā | Ā |
āPositive | 2.86 | 0.000 | 2.11ā3.88 | 3.36 | 0.000 | 2.41ā4.69 | 1.85 | 0.116 | 0.86ā3.99 |
Unplanned Readmission After Surgery | |||||||||
āNo Unplanned Readmiss | Reference | Ā | Ā | Ā | Ā | Ā | Ā | Ā | Ā |
āUnplanned Readmission | 0.69 | 0.121 | 0.43ā1.1 | 0.69 | 0.192 | 0.4ā1.2 | 0.67 | 0.374 | 0.27ā1.62 |
Inpatient Days after Surgery; mean (95% CI) | 1.00 | 0.801 | 0.99ā1.01 | 1.00 | 0.942 | 0.99ā1.01 | 1.01 | 0.164 | 0.99ā1.03 |
Days from Dx to Surgery; mean (95% CI) | 1.00 | 0.602 | 1ā1 | 1.00 | 0.144 | 1ā1 | 1.00 | 0.321 | 1ā1 |
Days from Dx to Treatment Commencing; mean (95% CI) | 1.00 | 0.020 | 1ā1.01 | 1.01 | 0.000 | 1ā1.01 | 1.00 | 0.528 | 0.99ā1 |