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Table 2 Clinicopathological variables of patients undergoing limb salvage surgery vs. amputation

From: Limb salvage versus amputation in patients with osteosarcoma of the extremities: an update in the modern era using the National Cancer Database

  Type of Surgery   p value
Limb Salvage Surgery Amputation Total
n % n % n %
Location
 Lower Limb 1536 82.8% 506 86.2% 2042 83.6% 0.053
 Upper Limb 319 17.2% 81 13.8% 400 16.4%
Long vs Short Bone
 Short Bone 51 2.8% 49 8.5% 100 4.1% p < 0.001
 Long Bone 1789 97.2% 527 91.5% 2316 95.9%
AJCC Clinical Stage
 Stage 2A or 2B 1509 81.3% 438 74.6% 1947 79.7% p = 0.002
 Stage 3 63 3.4% 25 4.3% 88 3.6%
 Stage 4A or 4B 283 15.3% 124 21.1% 407 16.7%
Osteosarcoma Type
 Osteosarcoma NOS 1216 66.1% 407 70.7% 1623 67.2% 0.059
 Chondro/Fibroblastic 370 20.1% 111 19.3% 481 19.9%
 Telangiectatic 78 4.2% 24 4.2% 102 4.2%
 Central 108 5.9% 24 4.2% 132 5.5%
 Surface/Juxtacortical 68 3.7% 10 1.7% 78 3.2%
Tumor Size (cm); mean (95% CI) 11.6 11.0–12.1 13.1 12.2–13.9 11.9 11.5–12.4 0.005
 < 8 cm 547 30.6% 132 23.0% 679 28.7% p < 0.001
 > 8 cm 1242 69.4% 442 77.0% 1684 71.3%
Presence of Metastases at Dx
 No metastases 1549 84.7% 454 78.3% 2003 83.2% p < 0.001
 metastases 279 15.3% 126 21.7% 405 16.8%
Comorbidities at Dx
 No comorbidities 1714 92.4% 520 88.6% 2234 91.5% 0.004
 1 or more 141 7.6% 67 11.4% 208 8.5%
Received Adjuvant Chemotherapy
 No 81 4.4% 62 10.6% 143 5.9% p < 0.001
 Yes 1762 95.6% 521 89.4% 2283 94.1%
Sequence of Adjuvant Treatment
 Before 558 37.3% 170 38.7% 728 37.6% p < 0.001
 After 162 10.8% 88 20.0% 250 12.9%
 Before+After 777 51.9% 181 41.2% 958 49.5%
Surgical Margins
 Clear 1617 93.7% 541 96.6% 2158 94.4% p = 0.010
 Positive 108 6.3% 19 3.4% 127 5.6%
Unplanned Readmission After Surgery
 No Unplanned Readmiss 1727 96.2% 548 95.6% 2275 96.1% 0.537
 Unplanned Readmission 68 3.8% 25 4.4% 93 3.9%
Inpatient Days after Surgery; mean (95% CI) 6.7 6.3–7.1 6.3 5.6–7.1 6.6 6.3–7.1 0.3706
Days from Dx to Surgery; mean (95% CI) 96.1 94.1–98.1 91.8 87.6–96.1 95.1 93.3–96.9 0.049
Days from Dx to Treatment Commencing; mean (95% CI) 20.5 19.4–21.5 22.4 20.3–24.5 20.9 20.0–21.9 0.0796
Total 1855 75.96% 587 24.04% 2442 100%