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Table 3 Univariable and multivariable Cox analysis of OS in skull base chordoma patients

From: Mean platelet volume and platelet distribution width serve as prognostic biomarkers in skull base chordoma: a retrospective study

Variables Univariable analysis Multivariable analysis
HR 95% CI P value HR 95% CI P value
Age (> 55 versus ≤55 years) 1.852 1.072–3.198 0.027* 1.791 1.023–3.135 0.042*
Sex (female versus male) 0.975 0.613–1.551 0.916    
Tumour volume (> 20,000 versus ≤20000mm3) 1.697 1.056–2.728 0.029* NA NA 0.569
Texture (hard/moderate versus soft) 1.612 0.935–2.780 0.086    
Blood supply (poor/moderate versus rich) 0.523 0.314–0.870 0.013* NA NA 0.157
Pathology (chondroid versus classical) 0.493 0.283–0.861 0.013* NA NA 0.128
Brainstem involvement (yes versus no) 1.013 0.630–1.629 0.956    
Posterior cranial nerve involvement (yes versus no) 1.287 0.802–2.064 0.295    
Degree of resection (non-total versus total resection) 3.390 1.552–7.405 0.002* 2.585 1.172–5.704 0.019*
Postoperative radiotherapy (yes versus no) 0.794 0.479–1.317 0.371    
Tumour recurrence (yes versus no) 9.549 3.482–26.183 < 0.001* 7.460 2.701–20.599 < 0.001*
PLT (≥266 versus < 266) 1.499 0.902–2.494 0.119    
MPV (≥11.9 versus < 11.9) 1.957 1.090–3.514 0.025* NA NA 0.527
PDW (≥14.5 versus < 14.5) 2.013 1.191–3.405 0.009* 2.154 1.258–3.688 0.005*
  1. * indicate p < 0.05
  2. OS overall survival, HR hazard ratio, CI confidence interval, PLT platelet count, MPV mean platelet volume, PDW platelet distribution width, NA not acquired