Table 3 Association among serum lipids and clinicopathological parameters and surgical outcomes
| TC/HDL | ApoB, g/L | Lipoprotein, g/L | |||||||
|---|---|---|---|---|---|---|---|---|---|
|
≤ 10.08 (n = 187) |
> 10.08 (n = 65) | p |
≤ 0.9 (n = 87) |
> 0.9 (n = 165) | p |
≤ 72 (n = 141) |
> 72 (n = 111) | p | |
| Clinicopathological characteristics | |||||||||
| Tumor type | < 0.001 | < 0.001 | 0.004 | ||||||
| GBC | 64(34.2) | 2(3.1) | < 0.001 | 30(34.5) | 36(21.8) | 0.030 | 32(22.7) | 34(30.6) | 0.155 |
| ICC | 42(22.5) | 5(7.7) | 0.008 | 25(28.7) | 22(13.3) | 0.003 | 20(14.2) | 27(24.3) | 0.040 |
| ECC | 81(43.3) | 58(89.2) | < 0.001 | 32(36.8) | 107(64.8) | < 0.001 | 89(63.1) | 50(45.0) | 0.004 |
| BMI ≥ 23 kg/m2 | 122(65.2) | 3(4.6) | < 0.001 | 57(65.5) | 68(41.2) | < 0.001 | 59(41.8) | 66(59.5) | 0.005 |
| Alcohol | 40(21.4) | 21(32.3) | 0.077 | 17(19.5) | 44(26.7) | 0.209 | 32(22.7) | 29(26.1) | 0.528 |
| Fatty liver | 8(4.3) | 5(7.7) | 0.455 | 2(2.3) | 11(6.7) | 0.234 | 9(6.4) | 4(3.6) | 0.322 |
| Jaundice | 69(36.9) | 64(98.5) | < 0.001 | 32(36.8) | 101(61.2) | < 0.001 | 87(61.7) | 46(41.4) | 0.001 |
| Cardiovascular disease | 77(41.2) | 25(38.5) | 0.701 | 33(38.0) | 69(41.8) | 0.550 | 57(40.4) | 45(40.5) | 0.985 |
| Tumor size, cm | 0.029 | 0.882 | 0.637 | ||||||
| d ≤ 2 | 78(41.7) | 34(52.3) | 0.139 | 35(40.2) | 77(46.7) | 0.328 | 68(48.2) | 44(39.6) | 0.173 |
| 2 < d ≤ 3 | 40(21.4) | 19(29.2) | 0.198 | 21(24.1) | 38(23.0) | 0.843 | 32(22.7) | 27(24.3) | 0.762 |
| 3 < d ≤ 4 | 21(11.2) | 6(9.2) | 0.653 | 10(11.5) | 17(10.3) | 0.771 | 15(10.6) | 12(10.8) | 0.965 |
| d > 4 | 40(21.4) | 4(6.2) | 0.005 | 16(18.4) | 28(17.0) | 0.778 | 22(15.6) | 22(19.8) | 0.381 |
| Lymph node metastasis | 58(31.0) | 23(35.4) | 0.516 | 25(28.7) | 56(33.9) | 0.400 | 42(29.8) | 39(35.1) | 0.367 |
| Extrahepatic involvement | 96(51.3) | 62(95.4) | < 0.001 | 42(48.3) | 116(70.3) | 0.001 | 100(70.9) | 58(52.3) | 0.002 |
| Intrahepatic involvement | 67(35.8) | 14(21.5) | 0.034 | 35(40.2) | 46(27.9) | 0.046 | 40(28.4) | 41(36.9) | 0.148 |
| Gallbladder involvement | 69(36.9) | 9(13.8) | 0.001 | 36(41.4) | 42(25.5) | 0.009 | 39(27.7) | 39(35.1) | 0.203 |
| TNM | < 0.001 | 0.018 | 0.166 | ||||||
| I | 69(36.9) | 25(38.5) | 0.822 | 32(36.8) | 62(37.6) | 0.901 | 52(36.9) | 42(37.8) | 0.876 |
| II | 43(23.0) | 30(46.2) | < 0.001 | 17(19.5) | 56(33.9) | 0.017 | 47(33.3) | 26(23.4) | 0.085 |
| III | 75(40.1) | 10(15.4) | < 0.001 | 38(43.7) | 47(28.5) | 0.015 | 42(29.8) | 43(38.7) | 0.136 |
| High differentiation | 62(33.2) | 13(20.0) | 0.046 | 25(28.7) | 50(30.3) | 0.796 | 39(27.7) | 36(32.4) | 0.411 |
| Radical cure | 119(63.6) | 38(58.5) | 0.458 | 59(67.8) | 98(59.4) | 0.190 | 90(63.8) | 67(60.4) | 0.573 |
| R0 | 120(64.2) | 39(60.0) | 0.548 | 60(70.0) | 99(60.0) | 0.161 | 91(64.5) | 68(61.3) | 0.592 |
| CA199 > 37 U/mL | 113(60.4) | 60(92.3) | < 0.001 | 58(66.7) | 115(69.7) | 0.622 | 107(75.9) | 66(59.5) | < 0.001 |
| Surgical outcome | |||||||||
| Estimated blood loss, mL | 300(100–500) | 300(200–575) | 0.195 | 300(100–500) | 300(200–500) | 0.137 | 400(175–500) | 250(150–450) | 0.117 |
| Postoperative hospital days | 18.0(14.0–26.0) | 23.0(20.0–30.5) | < 0.001 | 18.0(15.0–26.0) | 20.5(16.0–28.0) | 0.385 | 20.5(16.0–28.0) | 18.0(15.0–27.0) | 0.079 |
| Postoperative complications | 57(30.5) | 24(36.9) | 0.338 | 29(33.3) | 52(31.5) | 0.622 | 52(36.9) | 29(26.1) | 0.070 |
| Bleeding | 3(1.6) | 6(9.2) | 0.014 | 1(1.1) | 8(4.8) | 0.251 | 9(6.4) | 0(0.0) | 0.018 |
| Infection | 29(15.5) | 17(26.2) | 0.056 | 13(14.9) | 33(20.0) | 0.323 | 32(22.7) | 14(12.6) | 0.040 |
| Liver dysfunction | 0(0.0) | 0(0.0) | – | 0(0.0) | 0(0.0) | – | 0(0.0) | 0(0.0) | – |
| Bile leakage | 3(1.6) | 0(0.0) | 0.571 | 0(0.0) | 3(1.8) | 0.553 | 0(0.0) | 3(2.7) | 0.084 |
| Ascites | 17(9.1) | 6(9.2) | 0.973 | 10(11.5) | 13(7.9) | 0.343 | 14(9.9) | 9(8.1) | 0.618 |
| Others | 24(12.8) | 10(15.4) | 0.604 | 14(16.1) | 20(12.1) | 0.380 | 20(14.2) | 14(12.6) | 0.717 |