Table 2 Univariate and multivariate cox proportional hazards analysis of clinicopathological variables

Age, years (≤60/> 60)

1.126(0.860–1.473)

0.388

–

–

Sex (Female/Male)

0.963(0.738–1.256)

0.780

–

–

BMI, kg/m² (< 18.5/18.5–23/≥23)

0.734(0.588–0.916)

0.006

0.913(0.594–1.405)

0.680

Alcohol (No/Yes)

1.088(0.803–1.474)

0.586

–

–

Fatty liver (No/Yes)

1.211(0.745–1.965)

0.438

–

–

Jaundice (No/Yes)

1.547(1.17–2.045)

0.002

1.441(0.709–2.931)

0.313

Cardiovascular diseases (No/Yes)

0.966(0.736–1.267)

0.801

–

–

Tumor size, cm (≤2/2–3/3–4/> 5)

1.028(0.913–1.158)

0.646

–

–

Lymph node metastasis (No/Yes)

2.301(1.752–3.022)

2.07e-09

2.776(1.860–4.144)

5.88e-07

Extrahepatic involvement (No/Yes)

1.398(1.04–1.878)

0.026

1.277(0.614–2.656)

0.513

Intrahepatic involvement (No/Yes)

1.386(1.047–1.835)

0.022

1.491(0.944–2.354)

0.087

Gallbladder involvement (No/Yes)

1.170(0.861–1.591)

0.314

Tumor differentiation (low/low-moderate/moderate/moderate-high/high/undefined)

0.781(0.705–0.865)

2.01e-06

0.840(0.723–0.977)

0.023

Radical cure (No/Yes)

0.381(0.292–0.498)

1.35e-12

0.285(0.174–0.464)

4.89e-07

R0 (No/Yes)

0.643 (0.493–0.839)

0.001

1.681(1.069–2.643)

0.025

TC (≤4.97/> 4.97)

0.800(0.552–1.158)

0.236

–

–

TG (≤0.9/> 0.9)

1.477(1.063–2.051)

0.020

1.022(0.456–2.288)

0.959

HDL (≤0.94/> 0.94)

0.676(0.516–0.886)

0.004

1.026(0.611–1.722)

0.924

LDL (≤2.18/> 2.18)

0.790(0.534–1.168)

0.238

–

–

TC/HDL (≤11.4/> 11.4)

1.404(1.061–1.858)

0.018

2.330(1.005–5.404)

0.049

TG/HDL (≤4.16/> 4.16)

1.355(1.022–1.797)

0.034

0.550(0.230–1.314)

0.178

ApoA1 (≤0.72/> 0.72)

0.694(0.520–0.927)

0.013

0.967(0.571–1.636)

0.900

ApoB (≤0.9/> 0.9)

1.368(1.051–1.842)

0.039

2.931(1.916–4.483)

7.12e-07

Lipoprotein (≤89/> 89)

1.630(1.188–2.235)

0.002

2.635(1.784–3.891)

1.12e-06

Albumin (≤35/> 35)

0.965(0.938–0.992)

0.001

1.157(0.686–1.953)

0.585

ALT (≤40/> 40)

1.339(0.995–1.802)

0.054

–

–

AST (≤40/> 40)

1.252(0.941–1.665)

0.123

–

–

GGT (≤45/> 45)

1.968(1.345–2.881)

4.96e-04

0.822(0.444–1.522)

0.534

ALP (≤135/> 135)

1.634(1.211–2.205)

0.001

0.734(0.386–1.397)

0.346

LDH (≤250/> 250)

1.401(0.996–1.971)

0.052

–

–

TBIL (≤17.1/> 17.1)

1.619(1.183–2.216)

0.002

1.311(0.720–2.385)

0.376

CA199 (≤37/> 37)

2.408(1.675–3.463)

2.12e-06

2.043(1.210–3.447)

0.007