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Table 3 Prognostic impact of clinical variables and biomarkers in multivariate Cox regression analysis in 179 OSCC patients

From: The Axin2-snail axis promotes bone invasion by activating cancer-associated fibroblasts in oral squamous cell carcinoma

 

Hazard ratio (95% CI)

p

Age

0.825 (0.482–1.410)

0.481

Sex

0.609 (0.339–1.093)

0.096

Lesion site

 Mandible

1

0.235

 Maxilla

0.618 (0.289–1.323)

0.215

 RMT

1.206 (0.608–2.392)

0.591

T stage

 T1

 

0.99

 T2

0.989 (0.319–3.066)

0.985

 T3

1.059 (0.119–9.453)

0.959

 T4

1.157 (0.386–3.467)

0.795

N stage

 Nx

 

0.014

 N0

1.927 (1.016–3.655)

0.044

 N1–3

3.424 (1.466–7.998)

0.004

Histologic grade

 WD

1

0.435

 MD

1.209 (0.592–2.467)

0.602

 PD

1.665 (0.730–3.798)

0.226

Perineural invasion

0.850 (0.321–2.247)

0.743

Vascular invasion

1.036 (0.457–2.350)

0.933

Bone invasion

1.357 (0.572–3.219)

0.489

Desmoplasia

2.491 (1.240–5.004)

0.01

Angiogenesis

1.449 (0.860–2.441)

0.164

Axin2

2.488 (1.358–4.559)

0.003

Snail

1.984 (1.097–3.588)

0.024

  1. WD well differenciated, MD moderately differentiated, PD poorly differentiated, 95% CI 95% confidence interval
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BMC Cancer

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