Table 2 Clinicopathological significance of Axin2 and Snail expression in 217 OSCC patients
Variables | Total | Axin2 | P | Snail | P | ||
|---|---|---|---|---|---|---|---|
Low | High | Low | High | ||||
Age | |||||||
 ≤ 61 | 113 | 65 (57.5) | 48 (42.5) | 0.211 | 60 (53.1) | 53 (46.9) | 0.46 |
 > 61 | 104 | 51 (49.0) | 53 (51.0) | 50 (48.1) | 54 (51.9) | ||
Sex | |||||||
 Male | 141 | 69 (48.9) | 72 (51.1) | 0.069 | 74 (52.5) | 67 (47.5) | 0.472 |
 Female | 76 | 47 (61.8) | 29 (38.2) | 36 (47.4) | 40 (52.6) | ||
Site | |||||||
 Mandible | 112 | 66 (58.9) | 46 (41.1) | 0.173 | 60 (53.6) | 52 (46.4) | 0.681 |
 Maxilla | 67 | 34 (50.7) | 33 (49.3) | 32 (47.8) | 35 (52.2) | ||
 RMT | 38 | 16 (42.1) | 22 (57.9) | 18 (47.4) | 20 (52.6) | ||
T stage | |||||||
 T1-T2 | 72 | 51 (70.8) | 21 (29.2) | < 0.001 | 44 (61.1) | 28 (38.9) | 0.031 |
 T3-T4 | 145 | 65 (44.8) | 80 (55.2) | 66 (45.5) | 79 (54.5) | ||
N stage | |||||||
 Nx | 48 | 31 (64.6) | 17 (35.4) | < 0.001 | 29 (60.4) | 19 (39.6) | < 0.001 |
 N0 | 95 | 62 (65.3) | 33 (34.7) | 57 (60.0) | 38 (40.0) | ||
 N1–3 | 74 | 23 (31.1) | 51 (68.9) | 24 (32.4) | 50 (67.6) | ||
Histologic grade | |||||||
 WD | 35 | 22 (62.9) | 13 (37.1) | 0.439 | 19 (54.3) | 16 (45.7) | 0.565 |
 MD | 149 | 78 (52.3) | 71 (47.7) | 77 (51.7) | 72 (48.3) | ||
 PD | 33 | 16 (48.5) | 17 (51.5) | 14 (42.4) | 19 (57.6) | ||
Perineural invasion | |||||||
 Negative | 202 | 110 (54.5) | 92 (45.5) | 0.279 | 105 (52.0) | 97 (48.0) | 0.163 |
 Postive | 15 | 6 (40.0) | 9 (60.0) | 5 (33.3) | 10 (66.7) | ||
Vascular invasion | |||||||
 Negative | 192 | 109 (56.8) | 83 (43.2) | 0.01 | 103 (53.6) | 89 (46.4) | 0.019 |
 Postive | 25 | 7 (28.0) | 18 (72.0) | 7 (28.0) | 18 (72.0) | ||
Bone invasion | |||||||
 Negative | 94 | 63 (67.0) | 31 (33.0) | < 0.001 | 56 (59.6) | 38 (40.4) | 0.028 |
 Postive | 123 | 53 (43.1) | 70 (56.9) | 54 (43.9) | 69 (56.1) | ||