Fig. 5

Independent model validation. (A1) Heatmap of TWC analysis of the GSE10667 validation cohort of 31 IPF and 15 healthy control lung tissues by 75 common signature genes. (B1) Heatmap of TWC analysis of the GSE118370 validation cohort of 6 NSCLC and 6 normal control lung tissues by 79 common signature genes. (A2) All validation samples of GSE10667 were assigned by IPF probabilities; the true phenotype of the samples is indicated by the color: 15 blue normal samples and 31 red IPF samples. (B2) All validation samples of GSE118370 were assigned by NSCLC probabilities; the true phenotype of the samples is indicated by the color: 6 blue normal samples and 6 red NSCLC samples. (A3) The ROC curve for the predicted IPF of GSE10667 lung samples by the prior IPF model; the area under the curve was 0.934. (B3) The ROC curve for the predicted NSCLC of GSE118370 lung samples by the prior NSCLC model; the area under the curve was 1.000