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Table 4 Univariate and multivariate COX regression analysis identified clinical factors associated with prognosis

From: Development and validation of a fourteen- innate immunity-related gene pairs signature for predicting prognosis head and neck squamous cell carcinoma

Variables Univariate analysis Multivariable analysis
HR 95%CI of HR P value HR 95%CI of HR P value
TCGA training datasets
 14-IRGPs signature
  Risk score (High/Low) 2.97 1.99–4.43 7.79E-08 2.53 1.54–4.13 0.0002
  Age 1.02 1.01–1.04 0.009 1.02 0.99–1.04 0.0550
  Gender (Male vs Female) 0.70 0.47–1.04 0.077 0.94 0.56–1.5 0.8236
  T3/T4 vs T1/T2 0.97 0.66–1.43 0.895 0.43 0.24–0.74 0.0025
  N1/N2/N3 VS N0 1.21 0.78–1.85 0.39 1.00 0.59–1.68 0.9985
  Stage IV vs Stage I/ II/III 1.97 1.31–2.95 0.001 2.65 1.46–4.78 0.0012
  G3/G4 vs G1/G2 1.16 0.76–1.77 0.491 0.94 0.57–1.52 0.7969
  Smoking vs Non-smoking 0.95 0.59–1.52 8.35E-01 0.85 0.48–1.49 0.5707
TCGA validation datasets
 14-IRGPs signature
  Risk score (High/Low) 1.96 1.32–2.91 7.93E-04 1.72 1.12–2.62 0.0123
  Age 1.02 0.99–1.04 0.064 1.02 0.99–1.03 0.1549
  Gender (Male vs Female) 0.77 0.51–1.17 0.223 0.79 0.47–1.31 0.3577
  T3/T4 vs T1/T2 1.75 1.13–2.71 0.011 2.05 1.17–3.59 0.0120
  N1/N2/N3 VS N0 1.29 0.87–1.91 0.209 1.39 0.86–2.23 0.1674
  Stage IV vs Stage I/ II/III 1.36 0.90–2.05 0.142 0.87 0.49–1.53 0.6379
  G3/G4 vs G1/G2 1.22 0.77–1.93 0.393 1.20 0.74–1.93 0.4439
  Smoking vs Non-smoking 1.33 0.82–2.15 0.247 1.34 0.77–2.31 0.2987
TCGA entire datasets
 14-IRGPs signature
  Risk score (High/Low) 2.54 1.92–3.35 6.51E-11 2.01 1.41–2.84 9.36E-05
  Age 1.02 1.01–1.03 0.0013 1.02 1.01–1.04 0.0087
  Gender (Male vs Female) 0.74 0.55–0.97 0.034 0.97 0.66–1.41 0.8830
  T3/T4 vs T1/T2 1.28 0.96–1.70 0.093 0.72 0.47–1.09 0.1107
  N1/N2/N3 VS N0 1.20 0.87–1.66 0.271 1.07 0.73–1.54 0.7276
  Stage IV vs Stage I/ II/III 1.65 1.24–2.20 6.20E-04 1.85 1.21–2.82 0.0046
  G3/G4 vs G1/G2 1.15 0.84–1.57 0.365 0.83 0.58–1.18 0.3067
  Smoking vs Non-smoking 1.14 0.81–1.59 0.45 1.07 0.7–1.63 0.7539
GSE65858
 14-IRGPs signature
  Risk score (High/Low) 1.94 1.27–2.97 0.0021 1.90 1.23–2.92 0.0035
  Age 1.03 1.01–1.05 0.0130 1.04 1.01–1.06 0.0036
  Gender (Male vs Female) 1.05 0.62–1.77 0.8680 1.06 0.62–1.82 0.8378
  T3/T4 vs T1/T2 2.92 1.81–4.72 1.23E-05 2.16 1.26–3.69 0.0049
  N1/N2/N3 VS N0 2.14 1.38–3.32 0.0007 1.39 0.73–2.65 0.3216
  Stage IV vs Stage I/ II/III 2.92 1.72–4.95 7.22E-05 1.55 0.68–3.55 0.2987
  Smoking vs Non-smoking 0.94 0.55–1.59 0.8210 1.14 0.64–2.03 0.6493