Preoperative circulating tumor cells to predict microvascular invasion and dynamical detection indicate the prognosis of hepatocellular carcinoma

Table 2 Factors for microvascular invasion on univariate and multivariate analyses

Variables	OR	Univariate Analysis		OR	Multivariate Analysis
Variables	OR	HR (95% CI)	P	OR	HR (95% CI)	P
Age	1.009	0.981 ~ 1.038	0.545		NA	NA
Sex, male versus female	0.734	0.232 ~ 2.317	0.598		NA	NA
HBsAg, positive versus negative	1.173	0.469 ~ 2.930	0.733		NA	NA
Liver cirrhosis, yes versus no	1.738	0.747 ~ 4.044	0.200		NA	NA
Child-Pugh score, B versus A	1.389	0.333 ~ 5.800	0.652		NA	NA
ALT	1.016	0.993 ~ 1.039	0.169		NA	NA
AFP (ng/ml) ≤ 400 versus > 400	14.571	5.718 ~ 37.135	< 0.001	6.702	2.149 ~ 33.354	0.002
ICG-R15 (%)	0.988	0.907 ~ 1.076	0.781		NA	NA
Tumor size	1.170	1.063 ~ 1.288	0.001	1.213	1.031 ~ 1.427	0.020
No. of tumors, multiple versus single	6.286	2.456 ~ 16.090	< 0.001	2.059	0.470 ~ 9.010	0.338
Tumor encapsulation, yes versus no	0.773	0.383 ~ 1.562	0.473		NA	NA
Edmondson stage, III-IV versus I-II	1.133	0.572 ~ 2.244	0.032	1.484	0.571 ~ 4.259	0.463
Ki67 (%)	1.027	1.011 ~ 1.044	0.003	0.994	0.968 ~ 1.021	0.664
PVTT, yes versus no	7.435	2.771 ~ 19.950	< 0.001	2.413	0.351 ~ 16.590	0.370
Satellite lesion, yes versus no	8.437	2.673 ~ 26.630	< 0.001	2.169	0.340 ~ 13.826	0.413
BCLC stage, 0 + A versus B + C	3.984	1.941 ~ 8.177	< 0.001	0.683	0.163 ~ 2.866	0.602
Preoperative CTC^5ml	1.935	1.500 ~ 2.488	< 0.001	1.757	1.344 ~ 2.295	< 0.001

ALT alanine transaminase, AFP alpha fetoprotein, HBsAg hepatitis B surface antigen, ICG R15 min (%) indocyanine green 15 min retention rate, PVTT portal vein tumor thrombosis, BCLC Barcelona Clinic Liver Cancer staging system, CTC circulating tumor cell

ISSN: 1471-2407