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Table 2 Factors for microvascular invasion on univariate and multivariate analyses

From: Preoperative circulating tumor cells to predict microvascular invasion and dynamical detection indicate the prognosis of hepatocellular carcinoma

Variables OR Univariate Analysis OR Multivariate Analysis
HR (95% CI) P HR (95% CI) P
Age 1.009 0.981 ~ 1.038 0.545   NA NA
Sex, male versus female 0.734 0.232 ~ 2.317 0.598   NA NA
HBsAg, positive versus negative 1.173 0.469 ~ 2.930 0.733   NA NA
Liver cirrhosis, yes versus no 1.738 0.747 ~ 4.044 0.200   NA NA
Child-Pugh score, B versus A 1.389 0.333 ~ 5.800 0.652   NA NA
ALT 1.016 0.993 ~ 1.039 0.169   NA NA
AFP (ng/ml) ≤ 400 versus > 400 14.571 5.718 ~ 37.135 < 0.001 6.702 2.149 ~ 33.354 0.002
ICG-R15 (%) 0.988 0.907 ~ 1.076 0.781   NA NA
Tumor size 1.170 1.063 ~ 1.288 0.001 1.213 1.031 ~ 1.427 0.020
No. of tumors, multiple versus single 6.286 2.456 ~ 16.090 < 0.001 2.059 0.470 ~ 9.010 0.338
Tumor encapsulation, yes versus no 0.773 0.383 ~ 1.562 0.473   NA NA
Edmondson stage, III-IV versus I-II 1.133 0.572 ~ 2.244 0.032 1.484 0.571 ~ 4.259 0.463
Ki67 (%) 1.027 1.011 ~ 1.044 0.003 0.994 0.968 ~ 1.021 0.664
PVTT, yes versus no 7.435 2.771 ~ 19.950 < 0.001 2.413 0.351 ~ 16.590 0.370
Satellite lesion, yes versus no 8.437 2.673 ~ 26.630 < 0.001 2.169 0.340 ~ 13.826 0.413
BCLC stage, 0 + A versus B + C 3.984 1.941 ~ 8.177 < 0.001 0.683 0.163 ~ 2.866 0.602
Preoperative CTC5ml 1.935 1.500 ~ 2.488 < 0.001 1.757 1.344 ~ 2.295 < 0.001
  1. ALT alanine transaminase, AFP alpha fetoprotein, HBsAg hepatitis B surface antigen, ICG R15 min (%) indocyanine green 15 min retention rate, PVTT portal vein tumor thrombosis, BCLC Barcelona Clinic Liver Cancer staging system, CTC circulating tumor cell