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Table 4 Multivariable Cox regression model for factors associated with overall survival and cancer-specific survival in patients with lung cancer

From: Impact of pre-existing cardiovascular disease on treatment patterns and survival outcomes in patients with lung cancer

Variable Overall survival Cancer specific survival
HR (95% Confidence Limit) P value HR (95% Confidence Limit) P value
Age group
  < =60 Reference   Reference  
 61–70 1.1 (1 to 1.1) 0.0005 1.1 (1 to 1.1) 0.0061
 71–80 1.1 (1 to 1.1) 0.0012 1 (1 to 1.1) 0.2039
  > 80 1.1 (1.1 to 1.2) < 0.0001 1.1 (1 to 1.1) 0.0037
Sex
 Female Reference   Reference  
 Male 1.2 (1.2 to 1.2) < 0.0001 1.2 (1.2 to 1.2) < 0.0001
Year of diagnosis 1 (1 to 1) 0.0012 1 (1 to 1) 0.1635
CCI score
 0 Reference   Reference  
 1 1 (0.9 to 1) 0.2999 1 (0.9 to 1) 0.145
  > 1 1.2 (1.1 to 1.2) < 0.0001 1.2 (1.1 to 1.2) < 0.0001
Cardiovascular disease
 Yes Reference   Reference  
 No 1.1 (1.1 to 1.2) < 0.0001 1.1 (1.1 to 1.1) < 0.0001
Histology
 Adenocarcinoma Reference   Reference  
 SCC 1.1 (1 to 1.1) 0.0182 1 (1 to 1.1) 0.2506
 SCLC 1.6 (1.5 to 1.7) < 0.0001 1.6 (1.5 to 1.7) < 0.0001
 Carcinoid/LCNE 0.7 (0.7 to 0.8) < 0.0001 0.8 (0.7 to 0.9) < 0.0001
 Large cell ca 1.3 (1.1 to 1.4) 0.0011 1.3 (1.1 to 1.5) 0.0005
 Others 1.2 (1.2 to 1.3) < 0.0001 1.2 (1.2 to 1.3) < 0.0001
T stage
 T0 Reference   Reference  
 T1 1.3 (1 to 1.6) 0.0394 1.1 (0.9 to 1.4) 0.2457
 T2 1.8 (1.5 to 2.3) < 0.0001 1.8 (1.4 to 2.2) < 0.0001
 T3 2.5 (2 to 3.1) < 0.0001 2.4 (1.9 to 3) < 0.0001
 T4 2.6 (2.1 to 3.2) < 0.0001 2.5 (2 to 3.1) < 0.0001
 Unknown 1.8 (1.4 to 2.2) < 0.0001 1.7 (1.4 to 2.2) < 0.0001
N stage
 N0 Reference   Reference  
 N1 1.4 (1.3 to 1.5) < 0.0001 1.5 (1.4 to 1.6) < 0.0001
 N2 1.8 (1.7 to 1.8) < 0.0001 1.9 (1.8 to 1.9) < 0.0001
 N3 1.8 (1.7 to 1.9) < 0.0001 1.9 (1.8 to 2) < 0.0001
 Unknown 1.6 (1.5 to 1.7) < 0.0001 1.7 (1.5 to 1.8) < 0.0001
M stage
 M0 Reference   Reference  
 M1 1.9 (1.8 to 1.9) < 0.0001 2 (1.9 to 2.1) < 0.0001
 Unknown 0.9 (0.8 to 1) 0.2007 0.9 (0.8 to 1.1) 0.2776
Lateral
 Bilateral Reference   Reference  
 Left 1.3 (1.1 to 1.5) 0.0001 1.3 (1.1 to 1.5) 0.0014
 Right 1.3 (1.2 to 1.5) < 0.0001 1.3 (1.1 to 1.5) 0.0005
 Unknown 2 (1.7 to 2.4) < 0.0001 1.9 (1.6 to 2.3) < 0.0001
Surgery type
 Pneumonectomy Reference   Reference  
 Lobectomy or segmental 0.7 (0.6 to 0.9) 0.0002 0.6 (0.5 to 0.8) < 0.0001
 Non-surgery 2.8 (2.4 to 3.3) < 0.0001 2.7 (2.3 to 3.3) < 0.0001
Chemotherapy
 No Reference   Reference  
 Yes 0.4 (0.4 to 0.4) < 0.0001 0.4 (0.4 to 0.4) < 0.0001
Radiation
 No Reference   Reference  
 Yes 0.6 (0.6 to 0.7) < 0.0001 0.6 (0.6 to 0.7) < 0.0001
Surgery institution type
 Academic Reference   Reference  
 Community 1 (1 to 1.1) 0.44 1 (1 to 1.1) 0.069
Driving time (hours)
 1 Reference   Reference  
 2 1 (1 to 1.1) 0.5613 1 (1 to 1.1) 0.4693
 3 0.9 (0.8 to 1) 0.0215 0.9 (0.8 to 1) 0.0073
Zone name
 Calgary Reference   Reference  
 Central 1.1 (1 to 1.1) 0.004 1.1 (1 to 1.1) 0.03
 Edmonton 1.1 (1 to 1.1) < 0.0001 1.1 (1.1 to 1.1) < 0.0001
 North 1.2 (1.1 to 1.3) < 0.0001 1.2 (1.1 to 1.3) < 0.0001
 South 1.2 (1.1 to 1.3) < 0.0001 1.2 (1.1 to 1.3) < 0.0001
Education levela
  < = 80% Reference   Reference  
  > 80% 1 (1 to 1) 0.3769 1 (1 to 1) 0.5999
Income level
  < = 46 k Reference   Reference  
  > 46 k 1 (1 to 1) 0.9992 1 (1 to 1) 0.8051
  1. CCI Charlson’s comorbidity index, SCC Squamous cell cancer, SCLC Small cell lung cancer, LCNE Large Cell Neuroendocrine tumor. a80% of residents have high school and above level of education in the neighborhood