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Table 4 Multivariable Cox regression model for factors associated with overall survival and cancer-specific survival in patients with lung cancer

From: Impact of pre-existing cardiovascular disease on treatment patterns and survival outcomes in patients with lung cancer

Variable

Overall survival

Cancer specific survival

HR (95% Confidence Limit)

P value

HR (95% Confidence Limit)

P value

Age group

  < =60

Reference

 

Reference

 

 61–70

1.1 (1 to 1.1)

0.0005

1.1 (1 to 1.1)

0.0061

 71–80

1.1 (1 to 1.1)

0.0012

1 (1 to 1.1)

0.2039

  > 80

1.1 (1.1 to 1.2)

< 0.0001

1.1 (1 to 1.1)

0.0037

Sex

 Female

Reference

 

Reference

 

 Male

1.2 (1.2 to 1.2)

< 0.0001

1.2 (1.2 to 1.2)

< 0.0001

Year of diagnosis

1 (1 to 1)

0.0012

1 (1 to 1)

0.1635

CCI score

 0

Reference

 

Reference

 

 1

1 (0.9 to 1)

0.2999

1 (0.9 to 1)

0.145

  > 1

1.2 (1.1 to 1.2)

< 0.0001

1.2 (1.1 to 1.2)

< 0.0001

Cardiovascular disease

 Yes

Reference

 

Reference

 

 No

1.1 (1.1 to 1.2)

< 0.0001

1.1 (1.1 to 1.1)

< 0.0001

Histology

 Adenocarcinoma

Reference

 

Reference

 

 SCC

1.1 (1 to 1.1)

0.0182

1 (1 to 1.1)

0.2506

 SCLC

1.6 (1.5 to 1.7)

< 0.0001

1.6 (1.5 to 1.7)

< 0.0001

 Carcinoid/LCNE

0.7 (0.7 to 0.8)

< 0.0001

0.8 (0.7 to 0.9)

< 0.0001

 Large cell ca

1.3 (1.1 to 1.4)

0.0011

1.3 (1.1 to 1.5)

0.0005

 Others

1.2 (1.2 to 1.3)

< 0.0001

1.2 (1.2 to 1.3)

< 0.0001

T stage

 T0

Reference

 

Reference

 

 T1

1.3 (1 to 1.6)

0.0394

1.1 (0.9 to 1.4)

0.2457

 T2

1.8 (1.5 to 2.3)

< 0.0001

1.8 (1.4 to 2.2)

< 0.0001

 T3

2.5 (2 to 3.1)

< 0.0001

2.4 (1.9 to 3)

< 0.0001

 T4

2.6 (2.1 to 3.2)

< 0.0001

2.5 (2 to 3.1)

< 0.0001

 Unknown

1.8 (1.4 to 2.2)

< 0.0001

1.7 (1.4 to 2.2)

< 0.0001

N stage

 N0

Reference

 

Reference

 

 N1

1.4 (1.3 to 1.5)

< 0.0001

1.5 (1.4 to 1.6)

< 0.0001

 N2

1.8 (1.7 to 1.8)

< 0.0001

1.9 (1.8 to 1.9)

< 0.0001

 N3

1.8 (1.7 to 1.9)

< 0.0001

1.9 (1.8 to 2)

< 0.0001

 Unknown

1.6 (1.5 to 1.7)

< 0.0001

1.7 (1.5 to 1.8)

< 0.0001

M stage

 M0

Reference

 

Reference

 

 M1

1.9 (1.8 to 1.9)

< 0.0001

2 (1.9 to 2.1)

< 0.0001

 Unknown

0.9 (0.8 to 1)

0.2007

0.9 (0.8 to 1.1)

0.2776

Lateral

 Bilateral

Reference

 

Reference

 

 Left

1.3 (1.1 to 1.5)

0.0001

1.3 (1.1 to 1.5)

0.0014

 Right

1.3 (1.2 to 1.5)

< 0.0001

1.3 (1.1 to 1.5)

0.0005

 Unknown

2 (1.7 to 2.4)

< 0.0001

1.9 (1.6 to 2.3)

< 0.0001

Surgery type

 Pneumonectomy

Reference

 

Reference

 

 Lobectomy or segmental

0.7 (0.6 to 0.9)

0.0002

0.6 (0.5 to 0.8)

< 0.0001

 Non-surgery

2.8 (2.4 to 3.3)

< 0.0001

2.7 (2.3 to 3.3)

< 0.0001

Chemotherapy

 No

Reference

 

Reference

 

 Yes

0.4 (0.4 to 0.4)

< 0.0001

0.4 (0.4 to 0.4)

< 0.0001

Radiation

 No

Reference

 

Reference

 

 Yes

0.6 (0.6 to 0.7)

< 0.0001

0.6 (0.6 to 0.7)

< 0.0001

Surgery institution type

 Academic

Reference

 

Reference

 

 Community

1 (1 to 1.1)

0.44

1 (1 to 1.1)

0.069

Driving time (hours)

 1

Reference

 

Reference

 

 2

1 (1 to 1.1)

0.5613

1 (1 to 1.1)

0.4693

 3

0.9 (0.8 to 1)

0.0215

0.9 (0.8 to 1)

0.0073

Zone name

 Calgary

Reference

 

Reference

 

 Central

1.1 (1 to 1.1)

0.004

1.1 (1 to 1.1)

0.03

 Edmonton

1.1 (1 to 1.1)

< 0.0001

1.1 (1.1 to 1.1)

< 0.0001

 North

1.2 (1.1 to 1.3)

< 0.0001

1.2 (1.1 to 1.3)

< 0.0001

 South

1.2 (1.1 to 1.3)

< 0.0001

1.2 (1.1 to 1.3)

< 0.0001

Education levela

  < = 80%

Reference

 

Reference

 

  > 80%

1 (1 to 1)

0.3769

1 (1 to 1)

0.5999

Income level

  < = 46 k

Reference

 

Reference

 

  > 46 k

1 (1 to 1)

0.9992

1 (1 to 1)

0.8051

  1. CCI Charlson’s comorbidity index, SCC Squamous cell cancer, SCLC Small cell lung cancer, LCNE Large Cell Neuroendocrine tumor. a80% of residents have high school and above level of education in the neighborhood