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Table 4 Odds ratio (OR) and Genetic Effects Models with and without Genetic Subestruture evaluation

From: Skin pigmentation polymorphisms associated with increased risk of melanoma in a case-control sample from southern Brazil

SNP Effect ORa IC (95%) P AUC IC (95%)
With Genetic Substructuring, n = 254
 rs1126809 Dominant 1.121 0.639–1.965 0.691 0.661 0.593–0.729
Additive 1.921 0.412–8.961 0.406 0.660 0.592–0.729
Recessive 1.999 0.444–9.003 0.367 0.660 0.592–0.728
 rs1129038 Dominant 2.121 1.105–4.070 0.024 0.714 0.651–0.777
Additive 0.510 0.220–1.183 0.117 0.714 0.651–0.777
Recessive 1.137 0.569–2.270 0.716 0.707 0.643–0.771
 rs1426654 Dominant 7.164 1.868–27.472 0.004 0.729 0.667–0.791
Additive 1.538 0.091–25.909 0.765 0.728 0.666–0.790
Recessive 0.509 0.029–8.937 0.644 0.697 0.632–0.763
 rs16891982 Dominant 2.188 1.077–4.443 0.030 0.687 0.621–0.754
Additive 0.081 0.008–0.782 0.030 0.692 0.626–0.758
Recessive 9.278 0.939–91.701 0.057 0.665 0.598–0.733
Without Genetic Substructuring. n = 225
 rs1126809 Dominant 1.180 0.645–2.157 0.591 0.682 0.611–0.753
Additive 3.077 0.502–18.849 0.188 0.688 0.618–0.758
Recessive 2.951 0.494–17.643 0.235 0.689 0.619–0.759
 rs1129038 Dominant 2.212 1.106–4.426 0.025 0.705 0.635–0.774
Additive 0.390 0.157–0.967 0.042 0.698 0.629–0.767
Recessive 1.501 0.715–3.151 0.283 0.695 0.625–0.765
 rs1426654 Dominant 13.966 1.711–113.995 0.014 0.725 0.659–0.790
Additive 0.000 0.000 0.998 0.713 0.659–0.788
Recessive 0.000 0.000 1.000 0.693 0.623–0.762
 rs16891982 Dominant 2.624 1.220–5.643 0.014 0.708 0.639–0.776
Additive 0.084 0.008–0.872 0.038 0.711 0.643–0.779
Recessive 9.261 0.902–95.118 0.061 0.688 0.618–0.757
  1. Abbreviations: SNP single nucleotide polymorphism, OR odds ratio, IC confidence interval
  2. aOR values was adjusted to the following risk factors: sex. Age. hair color. Skin type. Number of nevi. and African ancestry
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