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Table 4 Odds ratio (OR) and Genetic Effects Models with and without Genetic Subestruture evaluation

From: Skin pigmentation polymorphisms associated with increased risk of melanoma in a case-control sample from southern Brazil

SNP

Effect

ORa

IC (95%)

P

AUC

IC (95%)

With Genetic Substructuring, n = 254

 rs1126809

Dominant

1.121

0.639–1.965

0.691

0.661

0.593–0.729

Additive

1.921

0.412–8.961

0.406

0.660

0.592–0.729

Recessive

1.999

0.444–9.003

0.367

0.660

0.592–0.728

 rs1129038

Dominant

2.121

1.105–4.070

0.024

0.714

0.651–0.777

Additive

0.510

0.220–1.183

0.117

0.714

0.651–0.777

Recessive

1.137

0.569–2.270

0.716

0.707

0.643–0.771

 rs1426654

Dominant

7.164

1.868–27.472

0.004

0.729

0.667–0.791

Additive

1.538

0.091–25.909

0.765

0.728

0.666–0.790

Recessive

0.509

0.029–8.937

0.644

0.697

0.632–0.763

 rs16891982

Dominant

2.188

1.077–4.443

0.030

0.687

0.621–0.754

Additive

0.081

0.008–0.782

0.030

0.692

0.626–0.758

Recessive

9.278

0.939–91.701

0.057

0.665

0.598–0.733

Without Genetic Substructuring. n = 225

 rs1126809

Dominant

1.180

0.645–2.157

0.591

0.682

0.611–0.753

Additive

3.077

0.502–18.849

0.188

0.688

0.618–0.758

Recessive

2.951

0.494–17.643

0.235

0.689

0.619–0.759

 rs1129038

Dominant

2.212

1.106–4.426

0.025

0.705

0.635–0.774

Additive

0.390

0.157–0.967

0.042

0.698

0.629–0.767

Recessive

1.501

0.715–3.151

0.283

0.695

0.625–0.765

 rs1426654

Dominant

13.966

1.711–113.995

0.014

0.725

0.659–0.790

Additive

0.000

0.000

0.998

0.713

0.659–0.788

Recessive

0.000

0.000

1.000

0.693

0.623–0.762

 rs16891982

Dominant

2.624

1.220–5.643

0.014

0.708

0.639–0.776

Additive

0.084

0.008–0.872

0.038

0.711

0.643–0.779

Recessive

9.261

0.902–95.118

0.061

0.688

0.618–0.757

  1. Abbreviations: SNP single nucleotide polymorphism, OR odds ratio, IC confidence interval
  2. aOR values was adjusted to the following risk factors: sex. Age. hair color. Skin type. Number of nevi. and African ancestry