Treatment outcome and long-term follow-up of central nervous system germ cell tumor using upfront chemotherapy with subsequent photon or proton radiation therapy: a single tertiary center experience of 127 patients

Table 3 Characteristics of relapsed patients

Risk	Number	Primary site	Previous radiotherapy	Relapsed site	Time to relapse (days)	Survival
Low risk	1	Rt. BG	LFRT 39.6Gy (XRT)	Lt. medial temporal lobe	660	DOD
	2	Rt. BG	LFRT 39.6Gy (XRT)	Rt. frontal & anterior temporal lobe	1146	Alive
	3	Rt. BG	WV 19.8Gy + LFRT 19.8Gy (PRT)	Subependymal seeding	885	Alive
	4	Lt. BG	WV 19.8Gy + LFRT 19.8Gy (PRT)	Sellar area	2654	Alive
	5	suprasellar	Only chemotherapy	Biopsy track	102	Alive
High risk	1	3rd ventricle	CSI 23.4Gy + LFRT 30.6Gy (XRT)	Pineal gland	449	DOD
	2	Pineal gland	WV 23.4Gy + LFRT 30.6 (XRT)	Pineal gland	201	DOD
	3	Pineal gland	CSI 23.4Gy + LFRT 30.6Gy (XRT)	Pineal gland	365	DOD

Rt. right, BG basal ganglia, LFRT limited-field radiation therapy, Gy gray, Lt. left, DOD died of disease, XRT photon radiation therapy, WV whole ventricle, PRT proton radiation therapy, CSI craniospinal irradiation

ISSN: 1471-2407