Table 3 Univariate and multivariate analyses of OS

Gender

Female / Male

0.712 (0.492–1.032)

0.073

–

NI

Age (years)

<60/ ≥60

1.570 (1.083–2.277)

0.017

1.492 (0.994–2.240)

0.054

NE(×10⁹/L)

<7/≥7

1.764 (1.171–2.657)

0.007

1.080 (0.620–1.883)

0.785

LY(×10⁹/L)

<4/≥4

0.788 (0.250–2.482)

0.684

–

NI

HGB(g/L)

<100/≥100

0.869 (0.600–1.258)

0.458

–

NI

PLT(×10⁹/L)

<300/≥300

1.012 (0.699–1.466)

0.948

–

NI

ALT(U/L)

<40/≥40

1.424 (0.894–2.270)

0.137

–

NI

AST(U/L)

<45/≥45

1.279 (0.825–1.983)

0.272

–

NI

ALP(U/L)

<100/≥100

1.171 (0.680–2.017)

0.568

–

NI

GGT(U/L)

<50/≥50

0.953 (0.545–1.664)

0.867

–

NI

ALB(g/L)

<35/≥35

0.976 (0.629–1.514)

0.914

–

NI

TBIL (mmol/L)

<20.5/≥20.5

1.088 (0.701–1.688)

0.706

–

NI

IBIL (mmol/L)

<15/≥15

1.493 (1.030–2.166)

0.035

1.345 (0.895–2.021)

0.154

CRP (mg/L)

<8/≥8

1.189 (0.779–1.814)

0.422

–

NI

Tumor

differentiation

high/ moderate / poor

2.029 (1.421–2.895)

<0.001

1.669 (1.126–2.476)

0.011

1.082 (0.837–1.397)

0.548

–

NI

Macrovascular Invision

Absent/Present

1.998 (1.010–3.954)

0.047

1.521 (0.639–3.621)

0.344

Microvascular Invision

Absent/Present

1.592 (1.080–2.347)

0.019

1.098 (0.708–1.703)

0.678

LN metastasis

1.545 (1.066–2.240)

0.022

0.640 (0.276–1.487)

0.299

TNM Stage

IA/IB/IIA/IIB/III

1.208 (1.051–1.388)

0.008

1.035 (0.777–1.379)

0.814

CEA (μg/L)

<5/≥5

1.356 (1.030–2.289)

0.035

1.172 (0.771–1.283)

0.457

CA199(U/mL)

<35/≥35

2.075 (1.289–3.339)

0.003

1.250 (0.745–2.096)

0.398

Chemotherapy

Absent/Present

0.816 (0.562–1.186)

0.286

–

NI

LNMS

1.574 (1.199–2.067)

0.001

1.786 (0.882–3.618)

0.107

PLNR

≤0.167/>0.167

1.367 (0.870–2.150)

0.176

–

NI

NLR

≤3.32/>3.32

1.599 (1.104–2.317)

0.013

0.820 (0.399–1.683)

0.588

dNLR

≤1.94/>1.94

1.451 (1.002–2.101)

0.049

0.894 (0.478–1.673)

0.726

PLR

≤99.02/>99.02

1.389 (0.676–2.853)

0.371

–

NI

PI

0 / 1 / 2

1.216 (0.906–1.633)

0.193

–

NI

PNI

0 / 1

1.063 (0.693–1.632)

0.778

–

NI

mGPS

0/1/2

0.996 (0.784–1.264)

0.971

–

NI

NLR-PI

1 / 2 / 3

1.570 (1.192–2.068)

0.001

1.684 (1.015–2.796)

0.044