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Table 5 Altered genes in the drug-resistant variants determined by DNA microarray analysis

From: Venetoclax and alvocidib are both cytotoxic to acute myeloid leukemia cells resistant to cytarabine and clofarabine

Upregulated

Downregulated

Gene

Ref. sequence

Fold change

Gene

Ref. sequence

Fold change

HL-60/

Ara-C10

HL-60/

CAFdA4

HL-60/

CAFdA30

HL-60/

Ara-C10

HL-60/

CAFdA4

HL-60/

CAFdA30

CDK7

NM_001799

3.12

2.83

2.83

CDA

NM_001785

0.46

0.47

0.49

CCND1

NM_053056

9.51

11.7

10.4

BCL2L11

NM_207002

0.35

0.35

0.31

CCND2

NM_001759

4.0

4.0

4.1

JAK2

NM_001322194

0.32

0.26

0.22

CCNB1

NM_031966

3.23

3.10

3.0

STAT5A

NM_003152

0.05

0.16

0.13

CCNB3

NM_033031

2.91

3.76

4.06

SOCS6

NM_004232

0.40

0.37

0.26

HDAC2

NM_001527

3.89

3.68

4.08

PTPN2

NM_002828

0.40

0.40

0.40

E2F5

NM_001951

4.32

3.89

4.32

ERN1

NM_001433

0.44

0.47

0.47

RRAS2

NM_012250

5.46

5.82

5.74

     

MAP 3 K8

NM_005204

2.08

2.17

2.51

     

KITLG

NM_000899

488

410

425

     

MAP 3 K6

NM_004672

31.8

23.1

21.1

     

FGFR1

NM_023110

580

498

530

     

MAPT

NM_016835

125

97.0

105

     

FLAT4

NM_002020

5.82

6.23

6.23

     

EFNA4

NM_182690

6.36

6.54

7.78

     

LAMC1

NM_002293

440

360

393

     

PKN3

NM_013355

47.5

49.5

48.2

     
  1. There were 4804 genes that had variation compared to the parent strain in 60,901 total genes. Gene symbol were CDA: cytidine deaminase, BCL2L11: Bim
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BMC Cancer

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