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Table 5 Altered genes in the drug-resistant variants determined by DNA microarray analysis

From: Venetoclax and alvocidib are both cytotoxic to acute myeloid leukemia cells resistant to cytarabine and clofarabine

Upregulated Downregulated
Gene Ref. sequence Fold change Gene Ref. sequence Fold change
HL-60/
Ara-C10
HL-60/
CAFdA4
HL-60/
CAFdA30
HL-60/
Ara-C10
HL-60/
CAFdA4
HL-60/
CAFdA30
CDK7 NM_001799 3.12 2.83 2.83 CDA NM_001785 0.46 0.47 0.49
CCND1 NM_053056 9.51 11.7 10.4 BCL2L11 NM_207002 0.35 0.35 0.31
CCND2 NM_001759 4.0 4.0 4.1 JAK2 NM_001322194 0.32 0.26 0.22
CCNB1 NM_031966 3.23 3.10 3.0 STAT5A NM_003152 0.05 0.16 0.13
CCNB3 NM_033031 2.91 3.76 4.06 SOCS6 NM_004232 0.40 0.37 0.26
HDAC2 NM_001527 3.89 3.68 4.08 PTPN2 NM_002828 0.40 0.40 0.40
E2F5 NM_001951 4.32 3.89 4.32 ERN1 NM_001433 0.44 0.47 0.47
RRAS2 NM_012250 5.46 5.82 5.74      
MAP 3 K8 NM_005204 2.08 2.17 2.51      
KITLG NM_000899 488 410 425      
MAP 3 K6 NM_004672 31.8 23.1 21.1      
FGFR1 NM_023110 580 498 530      
MAPT NM_016835 125 97.0 105      
FLAT4 NM_002020 5.82 6.23 6.23      
EFNA4 NM_182690 6.36 6.54 7.78      
LAMC1 NM_002293 440 360 393      
PKN3 NM_013355 47.5 49.5 48.2      
  1. There were 4804 genes that had variation compared to the parent strain in 60,901 total genes. Gene symbol were CDA: cytidine deaminase, BCL2L11: Bim