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Table 3 The growth inhibition effects of venetoclax and ara-C in MV4–11 cell line

From: Venetoclax and alvocidib are both cytotoxic to acute myeloid leukemia cells resistant to cytarabine and clofarabine

Drug (nM) MV4–11
Venetoclax 692
Ara-C 3055
Venetoclax+ara-C 1012
  1. Cells were treated for 72 h with each agent at different concentrations,
  2. followed by the determination of IC50 using the XTT assay
  3. Venetoclax+ara-C; Cells were incubated for 72 h with 20 nM venetoclax
  4. CI was 0.42