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Table 1 Drug sensitivities

From: Venetoclax and alvocidib are both cytotoxic to acute myeloid leukemia cells resistant to cytarabine and clofarabine

Drug HL-60
nM
HL-60/ara-C10
nM (RR)
HL-60/CAFdA4
nM (RR)
HL-60/CAFdA30
nM (RR)
Ara-C 670 6900 (10) > 1000 > 1000
CAFdA 60 359 (6) 260 (4) 1780 (30)
Gemcitabine 3 302 (101) 339 (113) 2089 (696)
Cladribine 68 6154 (91) 44,700 (657) 62,100 (913)
50 nM venetoclax + ara-C   2320   
50 nM venetoclax + CAFdA    120 690
  1. The IC50 values were calculated by using the XTT assay. RR, relative resistance calculated as the ratio of the IC50 of HL-60/ara-C10, HL-60/CAFdA4, or HL-60/CAFdA30 cells relative to that of HL-60. 50 nM venetoclax + ara-C; Cells were incubated for 72 h with 50 nM venetoclax and with ara-C at different concentrations, 50 nM venetoclax + CAFdA; Cells were incubated for 72 h with 50 nM venetoclax and with CAFdA at different concentrations. Ara-C Cytarabine, CAFdA Clofarabine