TY - JOUR AU - Lei, Han AU - Wang, Kun AU - Jiang, Tongying AU - Lu, Jingjing AU - Dong, Xue AU - Wang, Feilong AU - Li, Qiang AU - Zhao, Liming PY - 2020 DA - 2020/10/02 TI - KIAA0101 and UbcH10 interact to regulate non-small cell lung cancer cell proliferation by disrupting the function of the spindle assembly checkpoint JO - BMC Cancer SP - 957 VL - 20 IS - 1 AB - Chromosome mis-segregation caused by spindle assembly checkpoint (SAC) dysfunction during mitosis is an important pathogenic factor in cancer, and modulating SAC function has emerged as a potential novel therapy for non-small cell lung cancer (NSCLC). UbcH10 is considered to be associated with SAC function and the pathological types and clinical grades of NSCLC. KIAA0101, which contains a highly conserved proliferating cell nuclear antigen (PCNA)-binding motif that is involved in DNA repair in cancer cells, plays an important role in the regulation of SAC function in NSCLC cells, and bioinformatics predictions showed that this regulatory role is related to UbcH10. We hypothesized KIAA0101 and UbcH10 interact to mediate SAC dysfunction and neoplastic transformation during the development of USCLC. SN - 1471-2407 UR - https://doi.org/10.1186/s12885-020-07463-3 DO - 10.1186/s12885-020-07463-3 ID - Lei2020 ER -