Table 1 Univariate analysis of clinicopathological baseline data affecting survival: Patient cohort was characterized according to listed parameters in the first column. Type of classification and distribution within the cohort as well as impact on survival including P-Value (logrank) is given for each parameter. Bold and underlined P-Values are meant to highlight those below 0.05. NA = cases where not for all patients baseline data was available
From: Impact of pre-OP independence in patients with limited brain metastases on long-term survival
| Parameter: | Classification | Distribution |
Impact on cancer specific survival (CSS) Hazard ratio [95%-CI] | P-Value (logrank) |
|---|---|---|---|---|
| Age |
< 63,6 > = 63.6 Min 34, Max 87 Mean 62 |
50% (50/100) 50% (50/100) |
Age > 63.6: 2.48 95% CI [1.62–3.81] | 1.8 × 10− 5 |
| Sex |
Male Female |
43% (43/100) 57% (57/100) |
Gender male: 1.62 95% CI [1.07–2.46] | 0.022 |
| Number of cerebral metastases |
Solitary > 1 |
44% (44/100) 56% (56/100) |
Multiple metastases: 1.53 95% CI [1–2.24] | 0.048 |
|
Extracranial metastases at diagnosis of brain metastasis NA = 1 |
Yes No |
33% (33/100) 66% (66/100) |
Present at surgery: 1.34 95% CI [0.86–2.07] | 0.19 |
|
Chemotherapy (CT) after brain surgery NA = 7 |
No Yes |
50% (50/100) 43% (43/100) | No postoperative CT: 1.19 95% CI [0.77–1.83] | 0.43 |
|
Radiotherapy (RT) after brain surgery NA = 1 |
No Yes |
70% (70/100) 29% (29/100) |
No postoperative RT: 1.75 95% CI [1.1–2.78] | 0.017 |
| Scores | ||||
| Katz Index (median) |
< 6 =6 |
47% (47/100) 53% (53/100) |
Impairment (< 6): 3.29 95% CI [2.13–5.07] | 9.6 × 10−9 |
| Barthel Index (median) |
<=90 > 90 |
66% (66/100) 33% (34/100) |
Impairment (<=90): 2.7 95% CI [1.69–4.33] | 1.5 × 10− 5 |
| Karnofsky Performance Score (median) |
< 60 > = 60 |
33% (33/100) 67% (67/100) |
Low Score (< 60): 3.55 95% CI [2.24–5.64] | 1.4 × 10− 8 |
| ECOG Scale (median) |
< 2 > = 2 |
36% (36/100) 64% (64/100) |
Low Score (< 2): 2.74 95% CI [1.73–4.34] | 9 × 10− 6 |
| ASA Classification (median) |
<=2 > 2 |
61% (61/100) 39% (39/100) |
Low Score (< 2): 1.28 95% CI [0.84–1.95] | 0.26 |