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Table 1 Univariate analysis of clinicopathological baseline data affecting survival: Patient cohort was characterized according to listed parameters in the first column. Type of classification and distribution within the cohort as well as impact on survival including P-Value (logrank) is given for each parameter. Bold and underlined P-Values are meant to highlight those below 0.05. NA = cases where not for all patients baseline data was available

From: Impact of pre-OP independence in patients with limited brain metastases on long-term survival

Parameter: Classification Distribution Impact on cancer specific survival (CSS)
Hazard ratio [95%-CI]
P-Value (logrank)
Age <  63,6
> = 63.6
Min 34, Max 87
Mean 62
50% (50/100)
50% (50/100)
Age > 63.6:
2.48 95% CI [1.62–3.81]
1.8 × 10− 5
Sex Male
Female
43% (43/100)
57% (57/100)
Gender male: 1.62
95% CI [1.07–2.46]
0.022
Number of cerebral metastases Solitary
>  1
44% (44/100)
56% (56/100)
Multiple metastases: 1.53
95% CI [1–2.24]
0.048
Extracranial metastases at diagnosis of brain metastasis
NA = 1
Yes
No
33% (33/100)
66% (66/100)
Present at surgery:
1.34 95% CI [0.86–2.07]
0.19
Chemotherapy (CT) after brain surgery
NA = 7
No
Yes
50% (50/100)
43% (43/100)
No postoperative CT: 1.19 95% CI [0.77–1.83] 0.43
Radiotherapy (RT) after brain surgery
NA = 1
No
Yes
70% (70/100)
29% (29/100)
No postoperative RT: 1.75
95% CI [1.1–2.78]
0.017
Scores
Katz Index (median) < 6
=6
47% (47/100)
53% (53/100)
Impairment (< 6): 3.29
95% CI [2.13–5.07]
9.6 × 10−9
Barthel Index (median) <=90
> 90
66% (66/100)
33% (34/100)
Impairment (<=90): 2.7
95% CI [1.69–4.33]
1.5 × 10− 5
Karnofsky Performance Score (median) < 60
> = 60
33% (33/100)
67% (67/100)
Low Score (< 60): 3.55
95% CI [2.24–5.64]
1.4 × 10− 8
ECOG Scale (median) < 2
> = 2
36% (36/100)
64% (64/100)
Low Score (< 2): 2.74
95% CI [1.73–4.34]
9 × 10− 6
ASA Classification (median) <=2
> 2
61% (61/100)
39% (39/100)
Low Score (< 2): 1.28
95% CI [0.84–1.95]
0.26