Table 1 Univariate analysis of clinicopathological baseline data affecting survival: Patient cohort was characterized according to listed parameters in the first column. Type of classification and distribution within the cohort as well as impact on survival including P-Value (logrank) is given for each parameter. Bold and underlined P-Values are meant to highlight those below 0.05. NA = cases where not for all patients baseline data was available
From: Impact of pre-OP independence in patients with limited brain metastases on long-term survival
Parameter: | Classification | Distribution | Impact on cancer specific survival (CSS) Hazard ratio [95%-CI] | P-Value (logrank) |
|---|---|---|---|---|
Age | < 63,6 > = 63.6 Min 34, Max 87 Mean 62 | 50% (50/100) 50% (50/100) | Age > 63.6: 2.48 95% CI [1.62–3.81] | 1.8 × 10− 5 |
Sex | Male Female | 43% (43/100) 57% (57/100) | Gender male: 1.62 95% CI [1.07–2.46] | 0.022 |
Number of cerebral metastases | Solitary > 1 | 44% (44/100) 56% (56/100) | Multiple metastases: 1.53 95% CI [1–2.24] | 0.048 |
Extracranial metastases at diagnosis of brain metastasis NA = 1 | Yes No | 33% (33/100) 66% (66/100) | Present at surgery: 1.34 95% CI [0.86–2.07] | 0.19 |
Chemotherapy (CT) after brain surgery NA = 7 | No Yes | 50% (50/100) 43% (43/100) | No postoperative CT: 1.19 95% CI [0.77–1.83] | 0.43 |
Radiotherapy (RT) after brain surgery NA = 1 | No Yes | 70% (70/100) 29% (29/100) | No postoperative RT: 1.75 95% CI [1.1–2.78] | 0.017 |
Scores | ||||
Katz Index (median) | < 6 =6 | 47% (47/100) 53% (53/100) | Impairment (< 6): 3.29 95% CI [2.13–5.07] | 9.6 × 10−9 |
Barthel Index (median) | <=90 > 90 | 66% (66/100) 33% (34/100) | Impairment (<=90): 2.7 95% CI [1.69–4.33] | 1.5 × 10− 5 |
Karnofsky Performance Score (median) | < 60 > = 60 | 33% (33/100) 67% (67/100) | Low Score (< 60): 3.55 95% CI [2.24–5.64] | 1.4 × 10− 8 |
ECOG Scale (median) | < 2 > = 2 | 36% (36/100) 64% (64/100) | Low Score (< 2): 2.74 95% CI [1.73–4.34] | 9 × 10− 6 |
ASA Classification (median) | <=2 > 2 | 61% (61/100) 39% (39/100) | Low Score (< 2): 1.28 95% CI [0.84–1.95] | 0.26 |