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Fig. 5 | BMC Cancer

Fig. 5

From: Therapeutic potential of a novel prodrug of green tea extract in induction of apoptosis via ERK/JNK and Akt signaling pathway in human endometrial cancer

Fig. 5

ProEGCG inhibits proliferation of endometrial carcinoma in vivo. a Schematic establishment of the xenograft model in this study. b Rl95–2 and (c) AN3 CA cells were injected subcutaneously into athymic nude mice. Tumors were allowed to grow to a size around 100 mm3 and were then orally treated with ProEGCG (50 mg/kg), EGCG (50 mg/kg) or vehicle (olive oil) (n = 5 for each group). The increment of tumor volume and changes of body weight were assessed longitudinally. d Evaluation of hemato-biochemical markers from plasma samples of tumor-bearing mice after treatment with ProEGCG. Full-length of the gels are presented in Supplementary Fig. 5. Data are presented as mean ± S.E.M. Significant differences from control: *P < 0.05 and **P < 0.01. ALP, alkaline phosphatase; ALT, alanine aminotransferase

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