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Table 4 Head and neck SPCs in CIN 2–3 LLETZ treated women. A comparison between literature and our study data

From: Risk of HPV-related extra-cervical cancers in women treated for cervical intraepithelial neoplasia

Author Year First lesion Value Head and Neck
Evans [26] 2003 CIN 3 SIR 1.2
Kalliala [6] 2005 CIN 1–3 SIR 1.7
Gaudet [10] 2014 CIN 2 SIR 0.47
   CIN 3 SIR 0.67
Ebisch [8] 2017 CIN 3 IRR 5.51
Suk [23] 2018 SCC SIR 1.4
Wang [16] 2020 SCC SIR 2.29
Our study   CIN 2–3 SIR 8.5
  1. Legenda:
  2. CIN Cervical Intraepithelial Neoplasia
  3. IRR Incidence Rate Ratio
  4. LLETZ Large Loop Excision of the Transformation Zone
  5. SCC Invasive Squamous Cell Carcinoma
  6. SIR Standardized Incidence Ratio