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Table 2 The prognostic factors identified in the univariate and multivariate Cox regression models in the training cohort incorporating covariates identified by the smallest AIC value

From: A nomogram for predicting survival in patients with de novo metastatic breast cancer: a population-based study

Characteristics Univariate Cox analysis Multivariate Cox analysis
Hazard ratio 95%CI p value Hazard ratio 95%CI p value
Age
 < =40 R    < 0.001 R    < 0.001
 < =60 1.328 1.148 1.537 < 0.001 1.231 1.062 1.427 0.006
 > 60 1.870 1.621 2.159 < 0.001 1.724 1.483 2.003 < 0.001
Race
 White R    < 0.001 R    < 0.001
 black 1.394 1.268 1.533 < 0.001 1.275 1.154 1.407 < 0.001
 Othersa 0.884 0.756 1.033 0.122 0.922 0.788 1.079 0.311
Marital status
 Unmarriedb R    < 0.001 R    < 0.001
 Married 0.666 0.616 0.719   0.751 0.694 0.813  
Histology
 IDC R    0.189 Not included    
 ILC 0.916 0.801 1.048 0.202     
 IDC and ILC 0.882 0.738 1.053 0.164     
Grade
 I R    < 0.001 R    < 0.001
 II 1.228 1.036 1.454 0.018 1.401 1.180 1.662 < 0.001
 III/IV 1.743 1.476 2.058 < 0.001 1.792 1.504 2.135 < 0.001
Subtype
 HR+/HER2- R    < 0.001 R    < 0.001
 HR−/HER2+ 0.988 0.860 1.135 0.862 0.972 0.835 1.132 0.715
 HR+/HER2+ 0.801 0.717 0.895 < 0.001 0.832 0.739 0.938 0.003
 HR−/HER2- 1.926 2.649 3.232 < 0.001 2.969 2.642 3.337 < 0.001
T stage
 T1 R    < 0.001 R    0.001
 T2 1.005 0.878 1.151 0.938 1.011 0.882 1.159 0.875
 T3 1.162 1.003 1.345 0.045 1.059 0.913 1.229 0.450
 T4 1.507 1.321 1.720 < 0.001 1.213 1.059 1.389 0.005
N stage
 N0 R    0.244 Not included    
 N1 0.930 0.811 1.066 0.298     
 N2 0.827 0.685 0.998 0.047     
 N3 0.966 0.810 1.151 0.696     
Bone metastasis
 No R    < 0.001 R    < 0.001
 Yes 0.856 0.787 0.932   1.208 1.099 1.327  
Brain metastasis
 No R    < 0.001 R    < 0.001
 Yes 2.314 2.040 2.626   1.962 1.724 2.233  
Liver metastasis
 No R    < 0.001 R    < 0.001
 Yes 1.534 1.416 1.661   1.728 1.586 1.883  
Lung metastasis
 No R    < 0.001 R    < 0.001
 Yes 1.570 1.453 1.697   1.335 1.228 1.452  
Surgery
 No R    < 0.001 R    < 0.001
 BCS 0.547 0.476 0.628 < 0.001 0.606 0.526 0.699 < 0.001
 Mastectomy 0.724 0.654 0.802 < 0.001 0.762 0.686 0.845 < 0.001
Radiotherapy
 No/Unknown R    0.003 Not included    
 Yes 0.885 0.818 0.958      
chemotherapy
 No/Unknown R    < 0.001 R    < 0.001
 Yes 0.674 0.624 0.727   0.564 0.516 0.617  
  1. aOther races included American Indian/Alaska Native, Asian or Pacific Islander
  2. bUnmarried included divorced, separated, widowed, single (never married) or domestic partner