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Table 1 The demographic, pathological and treatment information of MBC patients diagnosed at 2010–2016 in the SEER database

From: A nomogram for predicting survival in patients with de novo metastatic breast cancer: a population-based study

Characteristics

The initial cohort

The training cohort

The validating cohort

p value

Number

Percent (%)

Number

Percent (%)

Number

Percent (%)

Age

      

0.873

 <=40

824

10.3

556

10.4

268

10.1

 

 <=60

3462

43.4

2305

43.3

1157

43.5

 

 > 60

3700

46.3

2463

46.3

1237

46.5

 

Race

      

0.160

 White

5999

75.1

4016

75.4

1983

74.5

 

 Black

1339

16.8

898

16.9

441

16.6

 

 Othersa

648

8.1

410

7.7

238

8.9

 

Marital status

     

0.837

 Unmarriedb

4208

52.7

2801

52.6

1407

52.9

 

 Married

3778

47.3

2523

47.4

1255

47.1

 

Histology

      

0.615

 IDC

6845

85.7

4571

85.9

2274

85.4

 

 ILC

737

9.2

480

9.0

257

9.7

 

 IDC and ILC

404

5.1

273

5.1

131

4.9

 

Grade

      

0.936

I 

571

7.2

377

7.1

194

7.3

 

 II

3397

42.5

2269

42.6

1128

42.4

 

 III/IV

4018

50.3

2678

50.3

1340

50.3

 

Subtype

      

0.431

 HR+/HER2-

4602

57.6

3073

57.7

1529

57.4

 

 HR−/HER2+

782

9.8

504

9.5

278

10.4

 

 HR+/HER2+

1518

19.0

1009

19.0

509

19.1

 

 HR−/HER2-

1084

13.6

738

13.9

346

13.0

 

T stage

      

0.524

 T1

922

11.5

616

11.6

306

11.5

 

 T2

2829

35.4

1857

34.9

972

36.5

 

 T3

1514

19.0

1015

19.1

499

18.7

 

 T4

2721

34.1

1836

34.5

885

33.2

 

N stage

      

0.335

 N0

1740

21.8

1159

21.8

581

21.8

 

 N1

3856

48.3

2538

47.7

1318

49.5

 

 N2

1093

13.7

743

14.0

350

13.1

 

 N3

1297

16.2

884

16.6

413

15.5

 

Bone metastasis

      

0.420

 no

2121

26.6

1399

26.3

722

27.1

 

 yes

5865

73.4

3925

73.7

1940

72.9

 

Brain metastasis

     

0.661

 no

7438

93.1

4954

93.1

2484

93.3

 

 yes

548

6.9

370

6.9

178

6.7

 

Liver metastasis

      

0.716

 no

5616

70.3

3737

70.2

1879

70.6

 

 yes

2370

29.7

1587

29.8

783

29.4

 

Lung metastasis

      

0.907

 no

5231

65.5

3485

65.5

1746

65.6

 

 yes

2755

34.5

1839

34.5

916

34.4

 

Surgery

      

0.661

 No

5790

72.5

3843

72.2

1947

73.1

 

 BCS

832

10.4

560

10.5

272

10.2

 

 Mastectomy

1364

17.1

921

17.3

443

16.6

 

Radiotherapy

      

0.445

 No/Unknown

5189

65.0

3444

64.7

1745

65.6

 

 Yes

2797

35.0

1880

35.3

917

34.4

 

Chemotherapy

      

0.948

 No/Unknown

3049

38.2

2034

38.2

1015

38.1

 

 Yes

4937

61.8

3290

61.8

1647

61.9

 
  1. aOther races included American Indian/Alaska Native, Asian or Pacific Islander
  2. bUnmarried included divorced, separated, widowed, single (never married) or domestic partner