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Table 1 The demographic, pathological and treatment information of MBC patients diagnosed at 2010–2016 in the SEER database

From: A nomogram for predicting survival in patients with de novo metastatic breast cancer: a population-based study

Characteristics The initial cohort The training cohort The validating cohort p value
Number Percent (%) Number Percent (%) Number Percent (%)
Age        0.873
 <=40 824 10.3 556 10.4 268 10.1  
 <=60 3462 43.4 2305 43.3 1157 43.5  
 > 60 3700 46.3 2463 46.3 1237 46.5  
Race        0.160
 White 5999 75.1 4016 75.4 1983 74.5  
 Black 1339 16.8 898 16.9 441 16.6  
 Othersa 648 8.1 410 7.7 238 8.9  
Marital status       0.837
 Unmarriedb 4208 52.7 2801 52.6 1407 52.9  
 Married 3778 47.3 2523 47.4 1255 47.1  
Histology        0.615
 IDC 6845 85.7 4571 85.9 2274 85.4  
 ILC 737 9.2 480 9.0 257 9.7  
 IDC and ILC 404 5.1 273 5.1 131 4.9  
Grade        0.936
I  571 7.2 377 7.1 194 7.3  
 II 3397 42.5 2269 42.6 1128 42.4  
 III/IV 4018 50.3 2678 50.3 1340 50.3  
Subtype        0.431
 HR+/HER2- 4602 57.6 3073 57.7 1529 57.4  
 HR−/HER2+ 782 9.8 504 9.5 278 10.4  
 HR+/HER2+ 1518 19.0 1009 19.0 509 19.1  
 HR−/HER2- 1084 13.6 738 13.9 346 13.0  
T stage        0.524
 T1 922 11.5 616 11.6 306 11.5  
 T2 2829 35.4 1857 34.9 972 36.5  
 T3 1514 19.0 1015 19.1 499 18.7  
 T4 2721 34.1 1836 34.5 885 33.2  
N stage        0.335
 N0 1740 21.8 1159 21.8 581 21.8  
 N1 3856 48.3 2538 47.7 1318 49.5  
 N2 1093 13.7 743 14.0 350 13.1  
 N3 1297 16.2 884 16.6 413 15.5  
Bone metastasis        0.420
 no 2121 26.6 1399 26.3 722 27.1  
 yes 5865 73.4 3925 73.7 1940 72.9  
Brain metastasis       0.661
 no 7438 93.1 4954 93.1 2484 93.3  
 yes 548 6.9 370 6.9 178 6.7  
Liver metastasis        0.716
 no 5616 70.3 3737 70.2 1879 70.6  
 yes 2370 29.7 1587 29.8 783 29.4  
Lung metastasis        0.907
 no 5231 65.5 3485 65.5 1746 65.6  
 yes 2755 34.5 1839 34.5 916 34.4  
Surgery        0.661
 No 5790 72.5 3843 72.2 1947 73.1  
 BCS 832 10.4 560 10.5 272 10.2  
 Mastectomy 1364 17.1 921 17.3 443 16.6  
Radiotherapy        0.445
 No/Unknown 5189 65.0 3444 64.7 1745 65.6  
 Yes 2797 35.0 1880 35.3 917 34.4  
Chemotherapy        0.948
 No/Unknown 3049 38.2 2034 38.2 1015 38.1  
 Yes 4937 61.8 3290 61.8 1647 61.9  
  1. aOther races included American Indian/Alaska Native, Asian or Pacific Islander
  2. bUnmarried included divorced, separated, widowed, single (never married) or domestic partner