Table 2 Univariate and Multivariate Cox regression analysis of clinicopathological factors and protein expression levels in total patients

Age (65≥/65<)

1.0869

0.56–2.08

0.8012

–

–

–

1.2365

0.60–2.50

0.5563

–

–

–

Gender (male/female)

0.7341

0.33–1.61

0.4403

–

–

–

1.2665

0.45–3.49

0.6482

–

–

–

Pathological Stage (I/II-III)

1.7621

1.08–2.87

0.0232

1.1665

0.64–2.10

0.6097

2.4598

1.49–4.06

0.0004

2.0609

1.19–3.56

0.0096

Pathologic T (1/2–4)

2.0430

1.15–3.60

0.0134

2.4608

1.28–4.70

0.0065

1.7041

0.98–2.95

0.0576

–

–

–

Vascular Invasion (present/absent)

0.6360

0.38–1.04

0.0722

–

–

–

0.6629

0.40–1.09

0.1104

–

–

–

Lymphatic permeation (present/absent)

1.7469

1.06–2.86

0.0267

1.5167

0.88–2.61

0.1331

2.7949

1.64–4.74

0.0001

2.1239

1.19–3.76

0.0098

VEGFR2 protein expression (high/low)

3.2560

1.94–5.45

< 0.0001

3.4920

2.01–6.05

< 0.0001

2.0079

1.20–3.34

0.0073

2.1163

1.24–3.60

0.0059

TUBB3 protein expression (high/low)

1.3197

0.79–2.18

0.2787

–

–

–

1.5876

0.95–2.65

0.0769

–

–

–

STMN1 protein expression (high/low)

1.3547

0.80–2.26

0.2473

–

–

–

1.0824

0.65–1.80

0.7605

–

–

–

STXBP4 protein expression (Pos/Neg)

2.5395

1.40–4.60

0.0021

1.4777

0.79–2.75

0.2186

1.8387

1.02–3.29

0.0405

1.4788

0.81–2.69

0.2013

∆Np63 protein expression (Pos/Neg)

2.0070

1.15–3.48

0.0134

1.8673

1.05–3.30

0.0324

1.2518

0.74–2.11

0.4007

–

–

–

p53 protein expression (Pos/Neg)

0.8030

0.49–1.31

0.3805

–

–

–

0.8854

0.53–1.46

0.6335

–

–

–

PD-L1 protein expression (Pos/Neg)

1.0638

0.63–1.77

0.8117

–

–

–

1.1789

0.69–1.99

0.5398

–

–

–