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Table 2 Univariate and Multivariate Cox regression analysis of clinicopathological factors and protein expression levels in total patients

From: Distinctive roles of syntaxin binding protein 4 and its action target, TP63, in lung squamous cell carcinoma: a theranostic study for the precision medicine

Clinicopathological Factors Cox regression analysis of overall survival Cox regression analysis of disease-free survival
Univariate analysis Multivariate analysis Univariate analysis Multivariate analysis
RR 95% CI p_value RR 95% CI p_value RR 95% CI p_value RR 95% CI p_value
Age (65≥/65<) 1.0869 0.56–2.08 0.8012 1.2365 0.60–2.50 0.5563
Gender (male/female) 0.7341 0.33–1.61 0.4403 1.2665 0.45–3.49 0.6482
Pathological Stage (I/II-III) 1.7621 1.08–2.87 0.0232 1.1665 0.64–2.10 0.6097 2.4598 1.49–4.06 0.0004 2.0609 1.19–3.56 0.0096
Pathologic T (1/2–4) 2.0430 1.15–3.60 0.0134 2.4608 1.28–4.70 0.0065 1.7041 0.98–2.95 0.0576
Vascular Invasion (present/absent) 0.6360 0.38–1.04 0.0722 0.6629 0.40–1.09 0.1104
Lymphatic permeation (present/absent) 1.7469 1.06–2.86 0.0267 1.5167 0.88–2.61 0.1331 2.7949 1.64–4.74 0.0001 2.1239 1.19–3.76 0.0098
VEGFR2 protein expression (high/low) 3.2560 1.94–5.45 < 0.0001 3.4920 2.01–6.05 < 0.0001 2.0079 1.20–3.34 0.0073 2.1163 1.24–3.60 0.0059
TUBB3 protein expression (high/low) 1.3197 0.79–2.18 0.2787 1.5876 0.95–2.65 0.0769
STMN1 protein expression (high/low) 1.3547 0.80–2.26 0.2473 1.0824 0.65–1.80 0.7605
STXBP4 protein expression (Pos/Neg) 2.5395 1.40–4.60 0.0021 1.4777 0.79–2.75 0.2186 1.8387 1.02–3.29 0.0405 1.4788 0.81–2.69 0.2013
∆Np63 protein expression (Pos/Neg) 2.0070 1.15–3.48 0.0134 1.8673 1.05–3.30 0.0324 1.2518 0.74–2.11 0.4007
p53 protein expression (Pos/Neg) 0.8030 0.49–1.31 0.3805 0.8854 0.53–1.46 0.6335
PD-L1 protein expression (Pos/Neg) 1.0638 0.63–1.77 0.8117 1.1789 0.69–1.99 0.5398
  1. RR Relative risk, CI Confidence interval, p < 0.05 is considered statistically significant., calculated with continuous variables