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Table 2 Main features of studies for prognosis analysis

From: CircRNAs as potential biomarkers for the clinicopathology and prognosis of glioma patients: a meta-analysis

Author (ref.) year Country CircRNA Tumor type Expression Assay methods Case Cut-offvalue Tumor stage High level Low level Survival analysis HR 95%CI HR availability Follow-up months
Zhu [14] 2017 China circ-BRAF glioma down-regulation qRT-PCR 68 NA grade(I-IV) 33 35 OS 4.13 1.79–9.56 K-M curve 60
Wang [15] 2018 China circ-0001649 glioma down-regulation qRT-PCR 64 NA grade(I-IV) 32 32 OS 2.012 1.012–4 Reported 60
Qu [16] 2019 China circ-0079593 glioma up-regulation qRT-PCR 60 mean grade(I-IV) 30 30 OS 2.21 1.023–4.772 Reported 60
Lv [17] 2020 China circ-EPB41L5 GBM down-regulation qRT-PCR 45 median grade (IV) 23 22 OS 3.401 1.388–8.88 Reported 45
Duan [18] 2018 China circ-0074362 glioma up-regulation qRT-PCR 62 NA grade(I-IV) 30 32 OS 2.695 1.054–6.897 Reported 56
Zhang [19] 2019 China circ-0029426 glioma up-regulation qRT-PCR 59 mean grade(I-IV) 31 28 OS 2.007 1.006–4.002 Reported 60
Yang [20] 2019 China circ-POSTN glioma up-regulation qRT-PCR 58 mean grade(I-IV) 29 29 OS 2.1 0.74–5.91 K-M curve 60
Yang [21] 2019 China circ-0034642 glioma up-regulation qRT-PCR 68 mean grade(I-IV) 36 32 OS 1.75 0.84–3.63 K-M curve 60
Wang [22] 2019 China circ-0005198 glioma up-regulation qRT-PCR 44 fold change grade(I-IV) 22 22 OS 2.47 0.66–9.2 K-M curve 60
Meng [23] 2019 China circ-SCAF11 glioma up-regulation qRT-PCR 40 NA grade(I-IV) 20 20 OS 1.64 0.59–4.59 K-M curve 60
Lyu [10] 2020 China circ-0013520 glioma up-regulation qRT-PCR 92 mean grade(I-IV) 40 52 OS 1.85 0.98–3.48 K-M curve 31
Lyu [10] 2020 China circ-0004379 glioma up-regulation qRT-PCR 92 mean grade(I-IV) 42 50 OS 1.65 0.87–3.11 K-M curve 30
Lu [24] 2019 China circ-0001730 glioma up-regulation qRT-PCR 99 NA grade(I-IV) 49 50 OS 1.55 0.29–8.11 K-M curve 24
Liu [25] 2020 China circ-CDC45 glioma up-regulation qRT-PCR 50 median grade(I-IV) 25 25 OS 1.78 0.9–3.55 K-M curve 60
Ding [26] 2019 China circ-NFIX glioma up-regulation qRT-PCR 64 NA grade(I-IV) 36 28 OS 0.87 0.17–4.46 K-M curve 60
Chen [27] 2018 China circ-0000177 glioma up-regulation qRT-PCR 62 NA grade(I-IV) 26 36 OS 2.05 0.52–8.1 K-M curve 60
Chen [28] 2020 China circ-0074026 glioma up-regulation qRT-PCR 60 mean grade(I-IV) 30 30 OS 2.6 1.37–4.94 K-M curve 60
Li [35] 2018 China circ-ITCH glioma down-regulation qRT-PCR 60 NA grade(I-IV) 31 29 OS 2.326 1.204–5.431 Reported 80
Peng [36] 2019 China circ-CPA4 glioma up-regulation qRT-PCR 73 average grade(I-IV) 35 38 OS 3.98 1.23–12.94 K-M curve 42
  1. HR hazard ratio, CI Confidence interval, qRT-PCR quantitative reverse transcription-polymerase chain reaction, NA not available, OS overall survival, K-M Kaplan-Meier