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Table 1 The p values summary of the association between circRNAs and clinicopathological features

From: CircRNAs as potential biomarkers for the clinicopathology and prognosis of glioma patients: a meta-analysis

Author (ref.) year Country CircRNA Tumor type Expression Assay methods Case Cut-off value Gender Age Tumor size (cm) WHO grade Tumor location KPS Family history
Zhu [14] 2017 China circBRAF glioma down-regulation qRT-PCR 68 NA 0.331 0.011 1(5) < 0.001 NA 0.429 NA
Wang [15] 2018 China circ-0001649 glioma down-regulation qRT-PCR 64 NA 0.196 0.803 0.002(3) 0.023 0.297 NA 0.474
Qu [16] 2019 China circ-0079593 glioma up-regulation qRT-PCR 60 mean 0.789 0.17 0.009(3) 0.002 0.604 NA 0.506
Lv [17] 2020 China circ-EPB41L5 GBM down-regulation qRT-PCR 45 median 0.449 0.026 0.42(10cm3) NA NA 0.279 NA
Duan [18] 2018 China circ-0074362 glioma up-regulation qRT-PCR 62 NA 0.806 0.074 0.04(4) 0.005 NA NA NA
Zhang [19] 2019 China circ-0029426 glioma up-regulation qRT-PCR 59 mean 0.601 0.415 0.033(3) 0.036 0.105 NA 0.741
Yang [20] 2019 China circ-POSTN glioma up-regulation qRT-PCR 58 mean 0.787 0.77 0.033(3) 0.034 0.793 NA 0.505
Yang [21] 2019 China circ-0034642 glioma up-regulation qRT-PCR 68 mean 0.312 0.201 0.014(3) 0.003 0.219 NA 0.356
Wang [22] 2019 China circ-0005198 glioma up-regulation qRT-PCR 44 fold change 0.51 0.698 0.014(3) 0.012 0.543 NA 1
Meng [23] 2019 China circ-SCAF11 glioma up-regulation qRT-PCR 40 NA 0.612 0.153 0.015(3) 0.178 NA 0.317 NA
Lyu [10] 2020 China circ-0013520 glioma up-regulation qRT-PCR 92 mean 0.747 0.511 <  0.001(3) 0.004 NA 0.008 NA
Lyu [10] 2020 China circ-0004379 glioma up-regulation qRT-PCR 92 mean 0.799 0.641 <  0.001(3) 0.005 NA 0.006 NA
Lu [24] 2019 China circ-0001730 glioma up-regulation qRT-PCR 99 NA 0.132 0.611 NA 0.004 NA NA NA
Liu [25] 2020 China circ-CDC45 glioma up-regulation qRT-PCR 50 median 0.561 0.321 0.016(3) 0.01 0.571 NA 0.496
Ding [26] 2019 China circ-NFIX glioma up-regulation qRT-PCR 64 NA 0.4363 0.765 0.0262(3) 0.0177 NA NA NA
Chen [27] 2018 China circ-0000177 glioma up-regulation qRT-PCR 62 NA 0.451 0.198 0.01(4) 0.02 NA NA NA
Chen [28] 2020 China circ-0074026 glioma up-regulation qRT-PCR 60 mean 0.795 0.125 0.001(3) 0.017 0.288 NA 0.731
Zuo [29] 2019 China circ-SMAD7 glioma up-regulation qRT-PCR 46 NA 0.309 0.978 NA 0.014 NA 0.0002 NA
Zhan [30] 2019 China circ-PITX1 glioma up-regulation qRT-PCR 52 median 0.765 0.541 0.023(3) 0.025 0.406 NA 0.499
Xie [31] 2018 China circ-0012129 glioma up-regulation qRT-PCR 31 NA 0.578 0.551 NA 0.014 NA NA NA
Qian [32] 2019 China circ-0074027 glioma up-regulation qRT-PCR 50 median 0.529 0.345 0.045(3) 0.021 0.158 NA 0.479
Liu [33] 2019 China circ-001350 glioma up-regulation qRT-PCR 53 mean 0.266 0.76 0.013(3) 0.029 0.588 NA 0.392
He [34] 2020 China circ-MAPK4 glioma up-regulation qRT-PCR 30 NA 0.919 0.855 0.513(3) 0.044 NA NA NA
  1. qRT-PCR quantitative reverse transcription-polymerase chain reaction, NA not available, GBM glioblastoma multiforme