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Table 2 Univariate analysis of prognostic factors related to DDFS in patients with internal IM-SC LN recurrence

From: Clinicopathological features of breast cancer patients with internal mammary and/or supraclavicular lymph node recurrence without distant metastasis

Prognostic factor

Patients (n = 14)

Univariate analysis

HR

95% CI

P-value

Tumor size of primary tumora

 T1 and T2

12

   

 T3 and T4

2

2.455

0.472–12.778

0.286

Clinical LN status at diagnosis

 Negative

6

   

 Positive

8

11.43

1.402–93.175

0.023

Pathological LN status of primary tumor

 Negative

7

   

 Positive

7

6.637

1.358–32.438

0.019

Primary ER status

 Negative

5

   

 Positive

9

1.031

0.271–3.929

0.964

Primary HER2 status

 Negative

9

   

 Positive

5

1.063

0.667–1.695

1.063

Type of surgery

 Mastectomy

10

   

 Partial mastectomy

4

0.570

0.116–2.792

0.570

Perioperative Chemotherapy

 Yes

10

1.724

0.356–8.355

0.499

 No

4

   

Post mastectomy radiation therapy

 Yes

4

   

 No

10

5.435

1.202–24.581

0.028

Disease free interval

 ≤ 1 year

4

   

 > 1 year

10

0.396

0.95–1.638

0.201

Number of metastatic lymph nodes at recurrence

 ≤ 2 lymph nodes

8

   

 ≥ 3 lymph nodes

6

0.675

0.168–2.714

0.580

Number of regions of metastatic lymph nodes at recurrence

 1

12

   

 2

2

1.123

0.137–9.231

0.914

Hormone therapy after recurrence

 Yes

4

1.084

0.257–4.567

0.913

 No

10

   

Chemotherapy after recurrence

 Yes

9

0.422

0.1112–1.587

0.202

 No

5

   

Operation after recurrence

 Yes

2

   

 No

12

0.515

0.064–4.155

0.534

Radiation therapy after recurrence

 Yes

8

0.900

0.238–3.408

0.877

 No

6

   
  1. aTNM classification is shown based on the eighth edition of the Union for International Cancer Control staging system
  2. Under bar indicates values that are statistically significant (P < 0.05)
  3. CI Confidence interval, DDFS Distant disease-free survival, ER Estrogen receptor, HER2 Human epidermal growth factor receptor 2, IM-SC Internal mammary and/or supraclavicular, LN Lymph node