From: Treatment response lowers tumor symptom burden in recurrent and/or metastatic head and neck cancer
Explanatory factors (TAS cohort, N = 391) | N | Death | HR | 95% CI | p-value | |
---|---|---|---|---|---|---|
Univariate | ||||||
Age at study inclusion* | ≤ 65 years | 241 | 153 | 1 | – | |
> 65–75 years | 107 | 60 | 0.68 | 0.50–0.92 | 0.0126 | |
> 75 years | 43 | 28 | 0.94 | 0.62–1.38 | 0.7636 | |
Sex* | Male | 320 | 203 | 1 | – | |
Female | 71 | 38 | 0.66 | 0.46–0.92 | 0.0193 | |
Weight | Per 5 kg | 391 | 241 | 1.02 | 0.98–1.07 | 0.3531 |
Alcohol consumption | Never | 87 | 61 | 1 | – | |
Several times per month | 85 | 51 | 0.9 | 0.62–1.30 | 0.5689 | |
Several times per week or daily | 101 | 60 | 0.82 | 0.57–1.17 | 0.2731 | |
Missing | 118 | 69 | 0.74 | 0.52–1.04 | 0.0836 | |
Smoking habits | Never smoked | 102 | 60 | 1 | – | |
Former smoker | 148 | 94 | 1.16 | 0.84–1.61 | 0.3666 | |
Current smoker | 140 | 86 | 1.01 | 0.73–1.41 | 0.9393 | |
Charlson comorbidity index at study inclusion* | 0 | 188 | 110 | 1 | – | |
1 | 79 | 57 | 1.37 | 0.99–1.87 | 0.0559 | |
> 1 | 124 | 74 | 1.19 | 0.88–1.59 | 0.2545 | |
Chemotherapy/Radiotherapy | Radiotherapy only | 78 | 43 | 1 | – | |
Chemotherapy only | 309 | 195 | 1.17 | 0.85–1.64 | 0.3616 | |
Radio-chemotherapy | 4 | 3 | 1.82 | 0.44–5.00 | 0.3187 | |
Duration since initial diagnosis | Per month | 391 | 241 | 1 | 1.00–1.00 | 0.515 |
ECOG performance status at treatment initiation* | 0 | 65 | 31 | 1 | – | |
1 | 225 | 145 | 1.63 | 1.12–2.45 | 0.0133 | |
≥ 2 | 77 | 53 | 2.37 | 1.53–3.73 | 0.0001 | |
Unknown | 24 | 12 | 1.5 | 0.74–2.86 | 0.2309 | |
Location of primary tumor | Oropharynx | 93 | 56 | 1 | – | |
Hypopharynx | 74 | 45 | 1.26 | 0.84–1.86 | 0.2546 | |
Larynx | 42 | 26 | 1.25 | 0.77–1.96 | 0.3539 | |
Oral cavity | 89 | 59 | 1.18 | 0.82–1.71 | 0.3671 | |
Other | 63 | 35 | 1.01 | 0.66–1.53 | 0.961 | |
Multiple locations | 30 | 20 | 1.91 | 1.12–3.14 | 0.0134 | |
Disease progression at study inclusion | Local recurrence only | 198 | 125 | 1 | – | |
Distant metastases | 193 | 116 | 0.86 | 0.66–1.10 | 0.2276 | |
Overall VAS score* | Per 10 points | 276 | 166 | 1.12 | 1.05–1.20 | 0.0009 |
Multivariatea | ||||||
Overall VAS score | Per 10 points | 276 | 166 | 1.12 | 1.05–1.20 | 0.0009 |