Table 1 Comparison of a retrospective analysis of neoadjuvant treated pancreatic cancer patients with photon radiotherapy (IMRT) in our facility by Combs et al. [14] with a Phase I/II prospective trial investigating carbon ion radiotherapy in pancreatic cancer by Shinoto et al. [13]
Author | Number of patients | Number of fractions | Total dose in Gy (RBE) | Single dose in Gy (RBE) | 1 J OS [%] | 2 J OS [%] | Median OS [months] | Concurrent gemcitabine | |
|---|---|---|---|---|---|---|---|---|---|
Photons | Combs et al. | 57 | 25 | 54 | 2.2 | 36 | 8 | 11 | 300 mg/m2, weekly |
Carbon ions | Shinoto et al. | 72 | 12 | 43.2–55.2 | 3.6–4.6 | 73 | 35 | 19,6 | 400–1000 mg/m2; days 1, 8, 15 |