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Table 8 Logistic regression analysis to identify patients harboring the T790M substitution through liquid biopsy (n = 58)

From: Genetic diagnostic features after failure of initial treatment with epidermal growth factor receptor (EGFR)-tyrosine kinase inhibitors among non-small-cell lung cancer patients harboring EGFR mutations

Variables

Univariate Analyses

Multivariate Analysis

OR

95%CI

P-value

OR

95%CI

P-value

Original mutation; absent vs. present

42.2

4.77–373.6

0.001

NI

Bone metastases; absent vs. present

48.8

5.45–436.4

0.001

77.9

5.32–1140

0.001

Enlargement of Tumor size; < 12 mm vs 12 mm ≤

0.10

0.02–0.43

0.002

NI

Brain metastases; absent vs. present

7.39

1.77–30.8

0.006

NI

Detection of New tumor lesion; < 4 vs 4

7.39

1.77–30.8

0.006

14.5

1.38–151.2

0.026

Detection of New metastatic organ; 0 → 4

1.98

1.09–3.59

0.024

NI

New minor site metastases; absent vs. present

8.44

1.21–58.8

0.031

NI

Hepatic metastases; absent vs. present

5.50

0.94–32.2

0.059

NI

Minor site metastases; absent vs. present

5.50

0.94–32.2

0.059

NI

Mutation site at initial diagnosis; Exon19 Deletion vs. L858R

3.91

0.87–17.5

0.075

1.15

0.13–10.1

0.897

New hepatic metastases; absent vs. present

5.00

0.62–40.3

0.131

NI

  1. Abbreviations: OR Odds ratio; CI confidence interval; Variables with a p-value < 0.15 on univariate analysis were entered into multivariate logistical analysis by a simultaneous method. NI not included in the best multivariate logistic regression model