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Table 8 Logistic regression analysis to identify patients harboring the T790M substitution through liquid biopsy (n = 58)

From: Genetic diagnostic features after failure of initial treatment with epidermal growth factor receptor (EGFR)-tyrosine kinase inhibitors among non-small-cell lung cancer patients harboring EGFR mutations

Variables Univariate Analyses Multivariate Analysis
OR 95%CI P-value OR 95%CI P-value
Original mutation; absent vs. present 42.2 4.77–373.6 0.001 NI
Bone metastases; absent vs. present 48.8 5.45–436.4 0.001 77.9 5.32–1140 0.001
Enlargement of Tumor size; < 12 mm vs 12 mm ≤ 0.10 0.02–0.43 0.002 NI
Brain metastases; absent vs. present 7.39 1.77–30.8 0.006 NI
Detection of New tumor lesion; < 4 vs 4 7.39 1.77–30.8 0.006 14.5 1.38–151.2 0.026
Detection of New metastatic organ; 0 → 4 1.98 1.09–3.59 0.024 NI
New minor site metastases; absent vs. present 8.44 1.21–58.8 0.031 NI
Hepatic metastases; absent vs. present 5.50 0.94–32.2 0.059 NI
Minor site metastases; absent vs. present 5.50 0.94–32.2 0.059 NI
Mutation site at initial diagnosis; Exon19 Deletion vs. L858R 3.91 0.87–17.5 0.075 1.15 0.13–10.1 0.897
New hepatic metastases; absent vs. present 5.00 0.62–40.3 0.131 NI
  1. Abbreviations: OR Odds ratio; CI confidence interval; Variables with a p-value < 0.15 on univariate analysis were entered into multivariate logistical analysis by a simultaneous method. NI not included in the best multivariate logistic regression model